IBRNvsPSCHETF Comparison
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iShares Neuroscience and Healthcare ETF (IBRN) belongs to the Healthcare Technology segment. Invesco S&P SmallCap Health Care ETF (PSCH) is part of the US Health Care segment. IBRN's top 2 sector exposures are Healthcare and Non-Corporate. In contrast, PSCH's top sector exposures are Healthcare. IBRN is more expensive with a Total Expense Ratio (TER) of 0.47%, versus 0.29% for PSCH. IBRN is up 21.65% year-to-date (YTD) with +$2M in YTD flows. PSCH performs better with 24.27% YTD performance, and +$7M in YTD flows. Run a side-by-side ETF comparison of IBRN and PSCH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBRN vs PSCH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/03/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBRN PSCH | +7.31%+1.93% | +14.35%+22.03% | +21.65%+24.27% | +55.92%+32.44% | +75.03%+32.30% | n/a-14.40% |
| Flows | IBRN PSCH | +$2M+$13M | +$2M+$25M | +$2M+$7M | +$2M+$2M | +$759K-$110M | --$207M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBRN PSCH | +24.59%+17.02% | +25.79%+19.62% | +25.17%+21.91% | n/a+22.88% |
| Max drawdown | IBRN PSCH | -9.28%-2.96% | -9.28%-15.36% | -34.98%-22.80% | n/a-45.76% |
| Max drawdown duration | IBRN PSCH | 40d30d | 40d168d | 338d488d | n/a1760d |
Trading data
IBRN | PSCH | |
Last sale 9/3/2026 at 7:58 PM | $39.37 | $54.75 |
| Previous close 09/03/2026 | $39.46 | $54.88 |
| Consolidated volume 09/03/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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IBRN | PSCH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/3/2026 at 7:58 PM
Live
Closed
IBRN | PSCH | |
|---|---|---|
| Last price | $39.37 | $54.75 |
| 1D performance | -0.21% | -0.24% |
| AuM | $7.86 M | $185.17 M |
| E/R | 0.47% | 0.29% |
Characteristics
IBRN | PSCH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | Invesco |
| Benchmark | NYSE FactSet Global Neuro Biopharma and MedTech Index | S&P SmallCap 600 Capped Health Care Index |
| N° of holdings | 69 | 69 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | August 24, 2022 | April 7, 2010 |
| ESG | No | No |
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Exposure
Countries
IBRN
USA
73.57%
Other
26.43%
PSCH
USA
95.04%
Other
4.96%
Sectors
IBRN
Healthcare
99.87%
Other
0.13%
PSCH
Healthcare
100%
Other
0%
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Diversification
IBRN
Total weight of top 15 holdings out of 15
64.26%
PSCH
Total weight of top 15 holdings out of 15
48.1%
Top 15 holdings
Data as of July 31, 2026
IBRN
Dianthus Therapeutics, Inc.
5.45%
Xenon Pharmaceuticals, Inc.
4.83%
Praxis Precision Medicines, Inc.
4.72%
ACADIA Pharmaceuticals, Inc.
4.66%
Arrowhead Pharmaceuticals, Inc.
4.65%
Alkermes Plc
4.55%
Neurocrine Biosciences, Inc.
4.41%
Scholar Rock Holding Corp.
4.31%
PTC Therapeutics, Inc.
4.15%
Biogen, Inc.
4.15%
Axsome Therapeutics, Inc.
3.93%
argenx SE
3.82%
Denali Therapeutics, Inc.
3.76%
Dyne Therapeutics, Inc.
3.53%
Edgewise Therapeutics, Inc.
3.35%
PSCH
Glaukos Corp.
4.96%
Corcept Therapeutics, Inc.
4.64%
Alkermes Plc
4.21%
Protagonist Therapeutics, Inc.
4.20%
TG Therapeutics, Inc.
3.68%
PTC Therapeutics, Inc.
3.23%
Liquidia Corp.
3.19%
Teleflex, Inc.
3.11%
Ligand Pharmaceuticals, Inc.
3.01%
Indivior Pharmaceuticals, Inc.
2.55%
Merit Medical Systems, Inc.
2.52%
RadNet, Inc.
2.34%
Veracyte, Inc.
2.32%
ICU Medical, Inc.
2.17%
Concentra Group Holdings Parent, Inc.
1.96%
Frequently asked questions about IBRN and PSCH
How have the IBRN and PSCH ETFs performed in 2026?
As of September 3, 2026, IBRN is up 21.65% year-to-date (YTD), while PSCH has returned 24.27%. That puts PSCH better performer ahead so far this year.
Which ETF is attracting more investor money: IBRN or PSCH?
Year-to-date, the IBRN ETF saw +$2M in flows, compared to +$7M for PSCH.
Which ETF is more volatile: IBRN or PSCH?
Over the past year, IBRN had a volatility of 25.79%, while PSCH experienced 19.62%.
Which ETF is bigger: IBRN or PSCH?
As of September 3, 2026, IBRN holds $7.86 M in assets under management (AUM), while PSCH manages $185.17 M.
What sectors do the IBRN and PSCH ETFs invest in?
IBRN leans toward sectors like Healthcare. Meanwhile, PSCH focuses on Healthcare.
What are the top holdings of the IBRN ETF and PSCH ETF?
IBRN top holdings include Dianthus Therapeutics, Inc., Xenon Pharmaceuticals, Inc. and Praxis Precision Medicines, Inc.. PSCH holds in its top three: Glaukos Corp., Corcept Therapeutics, Inc. and Alkermes Plc.
Which ETF is more diversified: IBRN or PSCH?
IBRN holds 69 securities with 64.26% of its assets in the top 15. PSCH has 69 securities and a top 15 weight of 48.1%.
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