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IBRNvsFMEDETF Comparison

ETF 1

IBRN

iShares Neuroscience and Healthcare ETF

This fund is part of

Healthcare Technology

-0.09%

Full IBRN fund page

VS

ETF 2

FMED

Fidelity Disruptive Medicine ETF

This fund is part of

Multiple Trends

+1.05%

Full FMED fund page

iShares Neuroscience and Healthcare ETF (IBRN) belongs to the Healthcare Technology segment. Fidelity Disruptive Medicine ETF (FMED) is part of the Multiple Trends segment. IBRN's top 2 sector exposures are Healthcare and Non-Corporate. In contrast, FMED's top sector exposures are Healthcare. IBRN is less expensive with a Total Expense Ratio (TER) of 0.47%, versus 0.5% for FMED. IBRN is up 20.7% year-to-date (YTD) with +$2M in YTD flows. FMED performs worse with 17.18% YTD performance, and -$17M in YTD flows. Run a side-by-side ETF comparison of IBRN and FMED below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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IBRN vs FMED performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 09/04/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	IBRN FMED	+3.54%+10.74%	+11.63%+25.72%	+20.70%+17.18%	+54.32%+28.12%	+73.68%+32.78%	n/an/a
Flows	IBRN FMED	+$2M-	+$2M-	+$2M-$17M	+$2M-$14M	+$759K-$3M	--

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	IBRN FMED	+24.49%+25.39%	+25.81%+21.06%	+25.16%+19.21%	n/an/a
Max drawdown	IBRN FMED	-9.28%-7.15%	-9.28%-17.78%	-34.98%-19.20%	n/an/a
Max drawdown duration	IBRN FMED	40d29d	40d212d	338d267d	n/an/a

Trading data

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	IBRN	FMED
Last sale 9/4/2026 at 1:30 PM	$39.06
Previous close 09/03/2026	$39.37
Consolidated volume 09/03/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of August 31, 2026

1-year trailing difference

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FMED

is actively managed and doesn’t replicate an index

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	IBRN	FMED
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 9/4/2026 at 1:30 PM

Live

Closed

	IBRN	FMED
Last price	$39.06	–
1D performance	-0.80%	–
AuM	$7.80 M	$51.55 M
E/R	0.47%	0.5%

Characteristics

	IBRN	FMED
Management strategy	Passive	Active
Provider	iShares	Fidelity
Benchmark	NYSE FactSet Global Neuro Biopharma and MedTech Index	-
N° of holdings	69	74
Asset class	Equities	-
Trailing 12m distribution yield	Join	Join
Inception date	August 24, 2022	June 12, 2023
ESG	No	No

More IBRN data on Trackinsight

More FMED data on Trackinsight

Exposure

Countries

IBRN

USA

73.57%

Other

26.43%

FMED

USA

83.4%

Other

16.6%

Sectors

IBRN

Healthcare

99.87%

Other

0.13%

FMED

Healthcare

100%

Other

0%

Diversification

IBRN

Total weight of top 15 holdings out of 15

64.26%

FMED

Total weight of top 15 holdings out of 15

43.09%

Top 15 holdings

Data as of July 31, 2026

IBRN

Dianthus Therapeutics, Inc.

5.45%

Xenon Pharmaceuticals, Inc.

4.83%

Praxis Precision Medicines, Inc.

4.72%

ACADIA Pharmaceuticals, Inc.

4.66%

Arrowhead Pharmaceuticals, Inc.

4.65%

Alkermes Plc

4.55%

Neurocrine Biosciences, Inc.

4.41%

Scholar Rock Holding Corp.

4.31%

PTC Therapeutics, Inc.

4.15%

Biogen, Inc.

4.15%

Axsome Therapeutics, Inc.

3.93%

argenx SE

3.82%

Denali Therapeutics, Inc.

3.76%

Dyne Therapeutics, Inc.

3.53%

Edgewise Therapeutics, Inc.

3.35%

FMED

10X Genomics, Inc.

4.48%

Thermo Fisher Scientific, Inc.

3.98%

Danaher Corp.

3.86%

Lifestance Health Group, Inc.

3.15%

Alnylam Pharmaceuticals, Inc.

3.10%

argenx SE

2.99%

Cogent Biosciences, Inc.

2.98%

Revolution Medicines, Inc.

2.85%

Illumina, Inc.

2.62%

Intuitive Surgical, Inc.

2.34%

Kymera Therapeutics, Inc.

2.29%

UnitedHealth Group, Inc.

2.24%

Ascendis Pharma A/S

2.12%

Kiniksa Pharmaceuticals International Plc

2.06%

UCB SA

2.03%

Frequently asked questions about IBRN and FMED

How have the IBRN and FMED ETFs performed in 2026?

As of September 4, 2026, IBRN is up 20.7% year-to-date (YTD), while FMED has returned 17.18%. That puts IBRN better performer ahead so far this year.

Which ETF is attracting more investor money: IBRN or FMED?

Year-to-date, the IBRN ETF saw +$2M in flows, compared to -$17M for FMED.

Which ETF is more volatile: IBRN or FMED?

Over the past year, IBRN had a volatility of 25.81%, while FMED experienced 21.06%.

Which ETF is bigger: IBRN or FMED?

As of September 4, 2026, IBRN holds $7.80 M in assets under management (AUM), while FMED manages $51.55 M.

What sectors do the IBRN and FMED ETFs invest in?

IBRN leans toward sectors like Healthcare. Meanwhile, FMED focuses on Healthcare.

What are the top holdings of the IBRN ETF and FMED ETF?

IBRN top holdings include Dianthus Therapeutics, Inc., Xenon Pharmaceuticals, Inc. and Praxis Precision Medicines, Inc.. FMED holds in its top three: 10X Genomics, Inc., Thermo Fisher Scientific, Inc. and Danaher Corp..

IBRNvsFMEDETF Comparison

iShares Neuroscience and Healthcare ETF

Fidelity Disruptive Medicine ETF

IBRN vs FMED performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the IBRN and FMED ETFs performed in 2026?

As of September 4, 2026, IBRN is up 20.7% year-to-date (YTD), while FMED has returned 17.18%. That puts IBRN better performer ahead so far this year.

Which ETF is attracting more investor money: IBRN or FMED?

Year-to-date, the IBRN ETF saw +$2M in flows, compared to -$17M for FMED.

Which ETF is more volatile: IBRN or FMED?

Over the past year, IBRN had a volatility of 25.81%, while FMED experienced 21.06%.

Which ETF is bigger: IBRN or FMED?

As of September 4, 2026, IBRN holds $7.80 M in assets under management (AUM), while FMED manages $51.55 M.

What sectors do the IBRN and FMED ETFs invest in?

IBRN leans toward sectors like Healthcare. Meanwhile, FMED focuses on Healthcare.

What are the top holdings of the IBRN ETF and FMED ETF?

IBRN top holdings include Dianthus Therapeutics, Inc., Xenon Pharmaceuticals, Inc. and Praxis Precision Medicines, Inc.. FMED holds in its top three: 10X Genomics, Inc., Thermo Fisher Scientific, Inc. and Danaher Corp..

Which ETF is more diversified: IBRN or FMED?

IBRN holds 69 securities with 64.26% of its assets in the top 15. FMED has 74 securities and a top 15 weight of 43.09%.

Active Trader Report: Use of Leveraged & Inverse ETFs Way Up