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HELXvsXHEETF Comparison

ETF 1

HELX

Franklin Genomic Advancements ETF

This fund is part of

BioTech & Genomics

+0.29%

Full HELX fund page

VS

ETF 2

XHE

State Street SPDR S&P Health Care Equipment ETF

This fund is part of

US Health Care

-0.12%

Full XHE fund page

Franklin Genomic Advancements ETF (HELX) belongs to the BioTech & Genomics segment. State Street SPDR S&P Health Care Equipment ETF (XHE) is part of the US Health Care segment. HELX's top 3 sector exposures are Healthcare, Non-Energy Materials and Technology. In contrast, XHE's top sector exposures are Healthcare and Finance. HELX is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.35% for XHE. HELX is up 12.93% year-to-date (YTD) with +$6M in YTD flows. XHE performs worse with 2.14% YTD performance, and +$11M in YTD flows. Run a side-by-side ETF comparison of HELX and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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HELX vs XHE performance and flow charts

Performance

Cumulative Flows

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Data Services

Historic performance and flows

Data as of 09/11/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	HELX XHE	-1.05%-5.10%	+15.09%+9.79%	+12.93%+2.14%	+33.15%+9.32%	+37.37%+7.53%	-26.59%-30.21%
Flows	HELX XHE	-+$3M	+$4M+$12M	+$6M+$11M	+$8M-$245K	+$15M-$266M	+$4M-$382M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	HELX XHE	+24.44%+24.14%	+22.84%+22.69%	+21.42%+22.22%	+23.54%+24.84%
Max drawdown	HELX XHE	-6.59%-7.53%	-17.89%-18.20%	-29.16%-24.35%	-58.16%-49.37%
Max drawdown duration	HELX XHE	28d23d	206d207d	458d565d	1814d1773d

Trading data

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	HELX	XHE
Last sale 9/14/2026 at 1:30 PM	$41.56	$91.47
Previous close 09/11/2026	$40.99	$90.01
Consolidated volume 09/11/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of August 31, 2026

1-year trailing difference

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HELX

is actively managed and doesn’t replicate an index

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	HELX	XHE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 9/14/2026 at 1:30 PM

Live

Closed

	HELX	XHE
Last price	$41.56	$91.47
1D performance	+1.40%	+1.62%
AuM	$30.73 M	$168.78 M
E/R	0.5%	0.35%

Characteristics

	HELX	XHE
Management strategy	Active	Passive
Provider	Franklin Templeton	State Street Investment Management
Benchmark	-	S&P Health Care Equipment Select Industry Index
N° of holdings	66	66
Asset class	-	Equities
Trailing 12m distribution yield	Join	Join
Inception date	February 25, 2020	January 26, 2011
ESG	No	No

More HELX data on Trackinsight

More XHE data on Trackinsight

Exposure

Countries

HELX

USA

86.99%

Other

13.01%

XHE

USA

93.56%

Other

6.44%

Sectors

HELX

Healthcare

96.35%

Other

3.65%

XHE

Healthcare

98.72%

Other

1.28%

Diversification

HELX

Total weight of top 15 holdings out of 15

60.19%

XHE

Total weight of top 15 holdings out of 15

30.19%

Top 15 holdings

Data as of July 31, 2026

HELX

Guardant Health, Inc.

9.10%

Natera, Inc.

7.31%

Krystal Biotech, Inc.

6.17%

Ligand Pharmaceuticals, Inc.

4.48%

Adaptive Biotechnologies Corp.

4.33%

BridgeBio Pharma, Inc.

4.08%

United Therapeutics Corp.

3.52%

Eli Lilly & Co.

3.04%

Vertex Pharmaceuticals, Inc.

2.73%

SAMSUNG BIOLOGICS Co., Ltd.

2.72%

Travere Therapeutics, Inc.

2.67%

Corteva, Inc.

2.65%

AstraZeneca PLC

2.49%

Twist Bioscience Corp.

2.47%

Medpace Holdings, Inc.

2.44%

XHE

AtriCure, Inc.

2.14%

Glaukos Corp.

2.13%

Dentsply Sirona, Inc.

2.08%

Enovis Corp.

2.07%

Integer Holdings Corp.

2.07%

Butterfly Network, Inc.

2.06%

Neogen Corp.

2.05%

Artivion, Inc.

2.05%

Baxter International, Inc.

2.01%

CONMED Corp.

1.99%

Merit Medical Systems, Inc.

1.98%

QuidelOrtho Corp.

1.94%

ICU Medical, Inc.

1.88%

Tandem Diabetes Care, Inc.

1.88%

Inspire Medical Systems, Inc.

1.85%

Frequently asked questions about HELX and XHE

How have the HELX and XHE ETFs performed in 2026?

As of September 11, 2026, HELX is up 12.93% year-to-date (YTD), while XHE has returned 2.14%. That puts HELX better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or XHE?

Year-to-date, the HELX ETF saw +$6M in flows, compared to +$11M for XHE.

Which ETF is more volatile: HELX or XHE?

Over the past year, HELX had a volatility of 22.84%, while XHE experienced 22.69%.

Which ETF is bigger: HELX or XHE?

As of September 11, 2026, HELX holds $30.73 M in assets under management (AUM), while XHE manages $168.78 M.

What sectors do the HELX and XHE ETFs invest in?

HELX leans toward sectors like Healthcare. Meanwhile, XHE focuses on Healthcare.

What are the top holdings of the HELX ETF and XHE ETF?

HELX top holdings include Guardant Health, Inc., Natera, Inc. and Krystal Biotech, Inc.. XHE holds in its top three: AtriCure, Inc., Glaukos Corp. and Dentsply Sirona, Inc..

HELXvsXHEETF Comparison

Franklin Genomic Advancements ETF

State Street SPDR S&P Health Care Equipment ETF

HELX vs XHE performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the HELX and XHE ETFs performed in 2026?

As of September 11, 2026, HELX is up 12.93% year-to-date (YTD), while XHE has returned 2.14%. That puts HELX better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or XHE?

Year-to-date, the HELX ETF saw +$6M in flows, compared to +$11M for XHE.

Which ETF is more volatile: HELX or XHE?

Over the past year, HELX had a volatility of 22.84%, while XHE experienced 22.69%.

Which ETF is bigger: HELX or XHE?

As of September 11, 2026, HELX holds $30.73 M in assets under management (AUM), while XHE manages $168.78 M.

What sectors do the HELX and XHE ETFs invest in?

HELX leans toward sectors like Healthcare. Meanwhile, XHE focuses on Healthcare.

What are the top holdings of the HELX ETF and XHE ETF?

HELX top holdings include Guardant Health, Inc., Natera, Inc. and Krystal Biotech, Inc.. XHE holds in its top three: AtriCure, Inc., Glaukos Corp. and Dentsply Sirona, Inc..

Which ETF is more diversified: HELX or XHE?

HELX holds 66 securities with 60.19% of its assets in the top 15. XHE has 66 securities and a top 15 weight of 30.19%.

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