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HELXvsXHEETF Comparison

ETF 1
HELX

Franklin Genomic Advancements ETF

This fund is part of
BioTech & Genomics
-0.14%
VS
ETF 2
XHE

State Street SPDR S&P Health Care Equipment ETF

This fund is part of
US Health Care
-0.03%

Franklin Genomic Advancements ETF (HELX) belongs to the BioTech & Genomics segment. State Street SPDR S&P Health Care Equipment ETF (XHE) is part of the US Health Care segment. HELX's top 3 sector exposures are Health Care, Materials and Information Technology. In contrast, XHE's top sector exposures are Health Care,  HELX is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.35% for XHE. HELX is down -8.75% year-to-date (YTD) with +$2M in YTD flows. XHE performs better with -7.98% YTD performance, and -$12M in YTD flows. Run a side-by-side ETF comparison of HELX and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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HELX vs XHE performance and flow charts

Performance

024681012%Mar 30Apr 7Apr 14Apr 21Apr 28

Cumulative Flows

-25 M-20 M-15 M-10 M-5 M0 MMar 30Apr 7Apr 14Apr 21Apr 28

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Historic performance and flows
Data as of 04/28/2026
1M3MYTD1Y3Y5Y
Perf.
HELX
XHE
+4.76%+6.20%
-10.15%-6.51%
-8.75%-7.98%
+22.50%+2.12%
+10.89%-16.88%
-29.92%-36.24%
Flows
HELX
XHE
--$12M
--$8M
+$2M-$12M
+$8M-$41M
+$9M-$308M
+$14M-$410M
Volatility and drawdown
3M1Y3Y5Y
Volatility
HELX
XHE
+24.81%+23.19%
+20.87%+21.35%
+20.23%+21.34%
+23.69%+24.32%
Max drawdown
HELX
XHE
-15.26%-14.31%
-17.89%-18.20%
-29.16%-32.46%
-58.50%-49.90%
Max drawdown duration
HELX
XHE
89d61d
149d110d
458d1016d
1694d1699d
Trading data

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HELX
XHE
Last sale
4/28/2026 at 7:59 PM
$33.13
$78.64
Previous close
04/28/2026
$33.63
$81.23
Consolidated volume
04/28/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of March 31, 2026
1-year trailing difference

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HELX
is actively managed and doesn’t replicate an index

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HELX
XHE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 4/28/2026 at 7:59 PM
Live
Closed
HELX
XHE
Last price
$33.13
$78.64
1D performance
-1.49%
-3.19%
AuM$21.52 M$129.75 M
E/R0.5%0.35%
Characteristics
HELX
XHE
Management strategyActivePassive
ProviderFranklin TempletonState Street Investment Management
Benchmark-S&P Health Care Equipment Select Industry Index
N° of holdings5161
Asset class-Equities
Trailing 12m distribution yield
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Inception dateFebruary 25, 2020January 26, 2011
ESGNoNo
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Exposure

Countries

HELX
USA
87.6%
Other
12.4%
XHE
USA
92.19%
Other
7.81%

Sectors

HELX
Health Care
89.74%
Other
10.26%
XHE
Health Care
89.87%
Other
10.13%
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Diversification

HELX

Total weight of top 15 holdings out of 15

60.42%
XHE

Total weight of top 15 holdings out of 15

26.74%

Top 15 holdings

Data as of March 31, 2026
HELX
NATERA
6.89%
GUARDANT HEALTH INC
6.82%
KRYSTAL BIOTECH INC
5.46%
UTD THERAPEUT
4.40%
BRIDGEBIO PHARMA
4.36%
INSMED
4.31%
LIGAND PHARMACEUTICALS
3.80%
SAMSUNG BIOLOGICS CO LTD
3.37%
ADAPTIVE BIOTECHNOLOGIES
3.32%
ASTRAZENECA
3.24%
VERTEX PHARMACEUTICALS
3.20%
MEDPACE HOLDINGS INC
3.05%
CORTEVA INC
2.81%
ALNYLAM PHARMACEUTICALS
2.71%
REGENERON PHARMACEUTICALS
2.67%
XHE
TELEFLEX
1.86%
STAAR SURGICAL
1.84%
BUTTERFLY NETWORK INC
1.84%
US58507V1070
1.83%
GLAUKOS
1.82%
INTEGER HOLDINGS
1.79%
AXOGEN
1.79%
LIVANOVA
1.78%
MASIMO
1.76%
LEMAITRE VASCULAR
1.75%
ARTIVION INC
1.75%
HOLOGIC
1.74%
STERIS
1.74%
GLOBUS MEDICAL
1.72%
IRHYTHM TECHNOLOGIES
1.72%
Frequently asked questions about HELX and XHE

How have the HELX and XHE ETFs performed in 2026?

As of April 28, 2026, HELX is down -8.75% year-to-date (YTD), while XHE has lost -7.98%. That puts XHE better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or XHE?

Year-to-date, the HELX ETF saw +$2M in flows, compared to -$12M for XHE.

Which ETF is more volatile: HELX or XHE?

Over the past year, HELX had a volatility of 20.87%, while XHE experienced 21.35%.

Which ETF is bigger: HELX or XHE?

As of April 28, 2026, HELX holds $21.52 M in assets under management (AUM), while XHE manages $129.75 M.

What sectors do the HELX and XHE ETFs invest in?

HELX leans toward sectors like Health Care. Meanwhile, XHE focuses on Health Care.

What are the top holdings of the HELX ETF and XHE ETF?

HELX top holdings include NATERA, GUARDANT HEALTH INC and KRYSTAL BIOTECH INC. XHE holds in its top three: TELEFLEX, STAAR SURGICAL and BUTTERFLY NETWORK INC.

Which ETF is more diversified: HELX or XHE?

HELX holds 60 securities with 60.42% of its assets in the top 15. XHE has 67 securities and a top 15 weight of 26.74%.

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