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HELXvsWDNAETF Comparison

ETF 1
HELX

Franklin Genomic Advancements ETF

This fund is part of
BioTech & Genomics
+3.75%
VS
ETF 2
WDNA

WisdomTree BioRevolution Fund

This fund is part of
BioTech & Genomics
+3.75%

Franklin Genomic Advancements ETF (HELX) and WisdomTree BioRevolution Fund (WDNA) belong to the same industry segment: BioTech & Genomics. HELX's top 3 sector exposures are Health Care, Materials and Information Technology. In contrast, WDNA's top sector exposures are Health Care, Materials and Consumer Staples. HELX is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.45% for WDNA. HELX is down -1.22% year-to-date (YTD) with +$2M in YTD flows. WDNA performs better with 8.2% YTD performance, and -$357K in YTD flows. Run a side-by-side ETF comparison of HELX and WDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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HELX vs WDNA performance and flow charts

Performance

-20246810%May 15May 22Jun 1Jun 8Jun 15

Cumulative Flows

May 15May 22Jun 1Jun 8Jun 15

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Historic performance and flows
Data as of 06/15/2026
1M3MYTD1Y3Y5Y
Perf.
HELX
WDNA
+9.44%+6.04%
+10.46%+5.78%
-1.22%+8.20%
+30.57%+45.12%
+14.77%+7.46%
-22.60%-25.27%
Flows
HELX
WDNA
--
--
+$2M-$357K
+$8M-$357K
+$9M-$524K
+$14M+$1M
Volatility and drawdown
3M1Y3Y5Y
Volatility
HELX
WDNA
+26.51%+24.35%
+21.11%+25.64%
+20.62%+24.91%
+23.64%+24.83%
Max drawdown
HELX
WDNA
-6.54%-9.07%
-17.89%-11.90%
-29.16%-37.80%
-58.50%-58.58%
Max drawdown duration
HELX
WDNA
38d57d
197d144d
458d901d
1742d1747d
Trading data

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HELX
WDNA
Last sale
6/15/2026 at 2:14 PM
$35.82
$18.31
Previous close
06/15/2026
$35.45
$18.01
Consolidated volume
06/15/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of June 16, 2026
1-year trailing difference

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HELX
is actively managed and doesn’t replicate an index

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HELX
WDNA
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 6/15/2026 at 2:14 PM
Live
Closed
HELX
WDNA
Last price
$35.82
$18.31
1D performance
+1.03%
+1.68%
AuM$23.30 M$2.38 M
E/R0.5%0.45%
Characteristics
HELX
WDNA
Management strategyActivePassive
ProviderFranklin TempletonWisdomTree
Benchmark-WisdomTree BioRevolution Index
N° of holdings5072
Asset class-Equities
Trailing 12m distribution yield
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Inception dateFebruary 25, 2020June 3, 2021
ESGNoNo
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Exposure

Countries

HELX
USA
87.65%
Other
12.35%
WDNA
USA
82.87%
Other
17.13%

Sectors

HELX
Health Care
89.42%
Other
10.58%
WDNA
Health Care
79.21%
Other
20.79%
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Diversification

HELX

Total weight of top 15 holdings out of 15

58.48%
WDNA

Total weight of top 15 holdings out of 15

39.77%

Top 15 holdings

Data as of April 30, 2026
HELX
NATERA
6.86%
GUARDANT HEALTH INC
6.56%
KRYSTAL BIOTECH INC
5.67%
UTD THERAPEUT
4.48%
LIGAND PHARMACEUTICALS
4.31%
BRIDGEBIO PHARMA
4.28%
INSMED
3.80%
ASTRAZENECA
3.26%
ADAPTIVE BIOTECHNOLOGIES
3.23%
SAMSUNG BIOLOGICS CO LTD
3.14%
VERTEX PHARMACEUTICALS
2.87%
REGENERON PHARMACEUTICALS
2.60%
CORTEVA INC
2.58%
ALNYLAM PHARMACEUTICALS
2.44%
LILLY
2.39%
WDNA
TWIST BIOSCIENCE CORP
3.90%
LILLY
3.44%
MODERNA INC
3.21%
JOHNSON&JOHNSON
3.16%
UTD THERAPEUT
3.07%
IMMUNOME
2.90%
DARLING INGREDIENTS INC
2.65%
STOKE THERAPEUTICS INC
2.46%
US88023B1035
2.34%
CORTEVA INC
2.22%
BEAM THERAPEUTICS
2.12%
ASTRAZENECA
2.12%
CH1300646267
2.12%
IONIS PHARMACEUTICALS INC
2.08%
NATERA
1.98%
Frequently asked questions about HELX and WDNA

How have the HELX and WDNA ETFs performed in 2026?

As of June 15, 2026, HELX is down -1.22% year-to-date (YTD), while WDNA has returned 8.2%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or WDNA?

Year-to-date, the HELX ETF saw +$2M in flows, compared to -$357K for WDNA.

Which ETF is more volatile: HELX or WDNA?

Over the past year, HELX had a volatility of 21.11%, while WDNA experienced 25.64%.

Which ETF is bigger: HELX or WDNA?

As of June 15, 2026, HELX holds $23.30 M in assets under management (AUM), while WDNA manages $2.38 M.

What sectors do the HELX and WDNA ETFs invest in?

HELX leans toward sectors like Health Care. Meanwhile, WDNA focuses on Health Care.

What are the top holdings of the HELX ETF and WDNA ETF?

HELX top holdings include NATERA, GUARDANT HEALTH INC and KRYSTAL BIOTECH INC. WDNA holds in its top three: TWIST BIOSCIENCE CORP, LILLY and MODERNA INC.

Which ETF is more diversified: HELX or WDNA?

HELX holds 60 securities with 58.48% of its assets in the top 15. WDNA has 80 securities and a top 15 weight of 39.77%.

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