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HELXvsWDNAETF Comparison

ETF 1

HELX

Franklin Genomic Advancements ETF

This fund is part of

BioTech & Genomics

-5.05%

Full HELX fund page

VS

ETF 2

WDNA

WisdomTree BioRevolution Fund

This fund is part of

BioTech & Genomics

-5.05%

Full WDNA fund page

Franklin Genomic Advancements ETF (HELX) and WisdomTree BioRevolution Fund (WDNA) belong to the same industry segment: BioTech & Genomics. HELX's top 3 sector exposures are Healthcare, Non-Energy Materials and Technology. In contrast, WDNA's top sector exposures are Healthcare, Non-Energy Materials and Consumer Non-Cyclicals. HELX is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.45% for WDNA. HELX is up 24.75% year-to-date (YTD) with +$8M in YTD flows. WDNA performs better with 42.28% YTD performance, and +$1M in YTD flows. Run a side-by-side ETF comparison of HELX and WDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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HELX vs WDNA performance and flow charts

Performance

Cumulative Flows

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Data Services

Historic performance and flows

Data as of 10/30/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	HELX WDNA	+1.74%+0.27%	+14.13%+20.95%	+24.75%+42.28%	+30.17%+48.19%	+78.56%+89.18%	-15.82%-1.48%
Flows	HELX WDNA	+$2M+$239K	+$2M+$2M	+$8M+$1M	+$8M+$1M	+$17M+$1M	+$8M+$3M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	HELX WDNA	+27.48%+38.53%	+24.12%+28.31%	+21.94%+26.80%	+23.68%+26.11%
Max drawdown	HELX WDNA	-8.93%-8.13%	-17.89%-11.90%	-29.16%-36.45%	-55.27%-56.39%
Max drawdown duration	HELX WDNA	22d38d	206d147d	458d595d	1823d1822d

Trading data

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	HELX	WDNA
Last sale 10/30/2026 at 1:30 PM	$45.25	$24.11
Previous close 10/29/2026	$46.01	$24.67
Consolidated volume 10/29/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of October 31, 2026

1-year trailing difference

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HELX

is actively managed and doesn’t replicate an index

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	HELX	WDNA
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 10/30/2026 at 1:30 PM

Live

Closed

	HELX	WDNA
Last price	$45.25	$24.11
1D performance	-1.65%	-2.29%
AuM	$36.21 M	$5.05 M
E/R	0.5%	0.45%

Characteristics

	HELX	WDNA
Management strategy	Active	Passive
Provider	Franklin Templeton	WisdomTree
Benchmark	-	WisdomTree BioRevolution ESG Screened Index
N° of holdings	66	79
Asset class	-	Equities
Trailing 12m distribution yield	Join	Join
Inception date	February 25, 2020	June 3, 2021
ESG	No	Yes

More HELX data on Trackinsight

More WDNA data on Trackinsight

Exposure

Countries

HELX

USA

90.13%

Other

9.87%

WDNA

USA

86.29%

Other

13.71%

Sectors

HELX

Healthcare

97.01%

Other

2.99%

WDNA

Healthcare

90.77%

Other

9.23%

Diversification

HELX

Total weight of top 15 holdings out of 15

61.42%

WDNA

Total weight of top 15 holdings out of 15

50.08%

Top 15 holdings

Data as of September 30, 2026

HELX

Natera, Inc.

10.25%

Guardant Health, Inc.

9.72%

Krystal Biotech, Inc.

5.32%

Twist Bioscience Corp.

5.01%

Adaptive Biotechnologies Corp.

4.95%

Ligand Pharmaceuticals, Inc.

4.33%

BridgeBio Pharma, Inc.

2.79%

Travere Therapeutics, Inc.

2.72%

Medpace Holdings, Inc.

2.64%

Vertex Pharmaceuticals, Inc.

2.62%

Corteva, Inc.

2.33%

Eli Lilly & Co.

2.25%

Tempus AI, Inc.

2.25%

United Therapeutics Corp.

2.20%

Repligen Corp.

2.04%

WDNA

Moderna, Inc.

10.44%

Twist Bioscience Corp.

9.31%

10X Genomics, Inc.

3.68%

Eli Lilly & Co.

3.47%

Natera, Inc.

3.09%

Tempus AI, Inc.

2.82%

Johnson & Johnson

2.69%

Iovance Biotherapeutics, Inc.

2.32%

Immunome, Inc.

2.02%

United Therapeutics Corp.

1.86%

Darling Ingredients, Inc.

1.85%

Thermo Fisher Scientific, Inc.

1.75%

Revolution Medicines, Inc.

1.60%

Corteva, Inc.

1.58%

CRISPR Therapeutics AG

1.58%

Frequently asked questions about HELX and WDNA

How have the HELX and WDNA ETFs performed in 2026?

As of October 30, 2026, HELX is up 24.75% year-to-date (YTD), while WDNA has returned 42.28%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or WDNA?

Year-to-date, the HELX ETF saw +$8M in flows, compared to +$1M for WDNA.

Which ETF is more volatile: HELX or WDNA?

Over the past year, HELX had a volatility of 24.12%, while WDNA experienced 28.31%.

Which ETF is bigger: HELX or WDNA?

As of October 30, 2026, HELX holds $36.21 M in assets under management (AUM), while WDNA manages $5.05 M.

What sectors do the HELX and WDNA ETFs invest in?

HELX leans toward sectors like Healthcare. Meanwhile, WDNA focuses on Healthcare.

What are the top holdings of the HELX ETF and WDNA ETF?

HELX top holdings include Natera, Inc., Guardant Health, Inc. and Krystal Biotech, Inc.. WDNA holds in its top three: Moderna, Inc., Twist Bioscience Corp. and 10X Genomics, Inc..

HELXvsWDNAETF Comparison

Franklin Genomic Advancements ETF

WisdomTree BioRevolution Fund

HELX vs WDNA performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the HELX and WDNA ETFs performed in 2026?

As of October 30, 2026, HELX is up 24.75% year-to-date (YTD), while WDNA has returned 42.28%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or WDNA?

Year-to-date, the HELX ETF saw +$8M in flows, compared to +$1M for WDNA.

Which ETF is more volatile: HELX or WDNA?

Over the past year, HELX had a volatility of 24.12%, while WDNA experienced 28.31%.

Which ETF is bigger: HELX or WDNA?

As of October 30, 2026, HELX holds $36.21 M in assets under management (AUM), while WDNA manages $5.05 M.

What sectors do the HELX and WDNA ETFs invest in?

HELX leans toward sectors like Healthcare. Meanwhile, WDNA focuses on Healthcare.

What are the top holdings of the HELX ETF and WDNA ETF?

HELX top holdings include Natera, Inc., Guardant Health, Inc. and Krystal Biotech, Inc.. WDNA holds in its top three: Moderna, Inc., Twist Bioscience Corp. and 10X Genomics, Inc..

Which ETF is more diversified: HELX or WDNA?

HELX holds 66 securities with 61.42% of its assets in the top 15. WDNA has 79 securities and a top 15 weight of 50.08%.

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