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HELXvsWDNAETF Comparison

ETF 1

HELX

Franklin Genomic Advancements ETF

This fund is part of

BioTech & Genomics

+0.29%

Full HELX fund page

VS

ETF 2

WDNA

WisdomTree BioRevolution Fund

This fund is part of

BioTech & Genomics

+0.29%

Full WDNA fund page

Franklin Genomic Advancements ETF (HELX) and WisdomTree BioRevolution Fund (WDNA) belong to the same industry segment: BioTech & Genomics. HELX's top 3 sector exposures are Healthcare, Non-Energy Materials and Technology. In contrast, WDNA's top sector exposures are Healthcare, Non-Energy Materials and Consumer Non-Cyclicals. HELX is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.45% for WDNA. HELX is up 12.93% year-to-date (YTD) with +$6M in YTD flows. WDNA performs better with 31.07% YTD performance, and +$326K in YTD flows. Run a side-by-side ETF comparison of HELX and WDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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HELX vs WDNA performance and flow charts

Performance

Cumulative Flows

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Historic performance and flows

Data as of 09/11/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	HELX WDNA	-1.05%+4.43%	+15.09%+23.49%	+12.93%+31.07%	+33.15%+55.75%	+37.37%+44.20%	-26.59%-11.83%
Flows	HELX WDNA	-+$683K	+$4M+$683K	+$6M+$326K	+$8M+$326K	+$15M+$159K	+$4M+$2M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	HELX WDNA	+24.44%+34.24%	+22.84%+28.01%	+21.42%+26.29%	+23.54%+25.74%
Max drawdown	HELX WDNA	-6.59%-9.35%	-17.89%-11.90%	-29.16%-36.45%	-58.16%-57.38%
Max drawdown duration	HELX WDNA	28d42d	206d147d	458d595d	1814d1814d

Trading data

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	HELX	WDNA
Last sale 9/14/2026 at 1:30 PM	$41.56	$22.14
Previous close 09/11/2026	$40.99	$22.11
Consolidated volume 09/11/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of September 14, 2026

1-year trailing difference

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HELX

is actively managed and doesn’t replicate an index

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	HELX	WDNA
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 9/14/2026 at 1:30 PM

Live

Closed

	HELX	WDNA
Last price	$41.56	$22.14
1D performance	+1.40%	+0.13%
AuM	$30.73 M	$3.55 M
E/R	0.5%	0.45%

Characteristics

	HELX	WDNA
Management strategy	Active	Passive
Provider	Franklin Templeton	WisdomTree
Benchmark	-	WisdomTree BioRevolution Index
N° of holdings	66	79
Asset class	-	Equities
Trailing 12m distribution yield	Join	Join
Inception date	February 25, 2020	June 3, 2021
ESG	No	No

More HELX data on Trackinsight

More WDNA data on Trackinsight

Exposure

Countries

HELX

USA

86.99%

Other

13.01%

WDNA

USA

83.75%

Other

16.25%

Sectors

HELX

Healthcare

96.35%

Other

3.65%

WDNA

Healthcare

88.38%

Non-Energy Materi.

7.38%

Other

4.25%

Diversification

HELX

Total weight of top 15 holdings out of 15

60.19%

WDNA

Total weight of top 15 holdings out of 15

40.46%

Top 15 holdings

Data as of July 31, 2026

HELX

Guardant Health, Inc.

9.10%

Natera, Inc.

7.31%

Krystal Biotech, Inc.

6.17%

Ligand Pharmaceuticals, Inc.

4.48%

Adaptive Biotechnologies Corp.

4.33%

BridgeBio Pharma, Inc.

4.08%

United Therapeutics Corp.

3.52%

Eli Lilly & Co.

3.04%

Vertex Pharmaceuticals, Inc.

2.73%

SAMSUNG BIOLOGICS Co., Ltd.

2.72%

Travere Therapeutics, Inc.

2.67%

Corteva, Inc.

2.65%

AstraZeneca PLC

2.49%

Twist Bioscience Corp.

2.47%

Medpace Holdings, Inc.

2.44%

WDNA

Twist Bioscience Corp.

5.53%

Eli Lilly & Co.

4.11%

Moderna, Inc.

3.59%

Johnson & Johnson

3.13%

Immunome, Inc.

2.57%

United Therapeutics Corp.

2.50%

10X Genomics, Inc.

2.44%

Natera, Inc.

2.42%

Darling Ingredients, Inc.

2.26%

Corteva, Inc.

2.19%

Structure Therapeutics, Inc.

2.04%

Stoke Therapeutics, Inc.

2.02%

Krystal Biotech, Inc.

2.01%

Thermo Fisher Scientific, Inc.

1.83%

Tempus AI, Inc.

1.82%

Frequently asked questions about HELX and WDNA

How have the HELX and WDNA ETFs performed in 2026?

As of September 11, 2026, HELX is up 12.93% year-to-date (YTD), while WDNA has returned 31.07%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or WDNA?

Year-to-date, the HELX ETF saw +$6M in flows, compared to +$326K for WDNA.

Which ETF is more volatile: HELX or WDNA?

Over the past year, HELX had a volatility of 22.84%, while WDNA experienced 28.01%.

Which ETF is bigger: HELX or WDNA?

As of September 11, 2026, HELX holds $30.73 M in assets under management (AUM), while WDNA manages $3.55 M.

What sectors do the HELX and WDNA ETFs invest in?

HELX leans toward sectors like Healthcare. Meanwhile, WDNA focuses on Healthcare and Non-Energy Materials.

What are the top holdings of the HELX ETF and WDNA ETF?

HELX top holdings include Guardant Health, Inc., Natera, Inc. and Krystal Biotech, Inc.. WDNA holds in its top three: Twist Bioscience Corp., Eli Lilly & Co. and Moderna, Inc..

HELXvsWDNAETF Comparison

Franklin Genomic Advancements ETF

WisdomTree BioRevolution Fund

HELX vs WDNA performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the HELX and WDNA ETFs performed in 2026?

As of September 11, 2026, HELX is up 12.93% year-to-date (YTD), while WDNA has returned 31.07%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or WDNA?

Year-to-date, the HELX ETF saw +$6M in flows, compared to +$326K for WDNA.

Which ETF is more volatile: HELX or WDNA?

Over the past year, HELX had a volatility of 22.84%, while WDNA experienced 28.01%.

Which ETF is bigger: HELX or WDNA?

As of September 11, 2026, HELX holds $30.73 M in assets under management (AUM), while WDNA manages $3.55 M.

What sectors do the HELX and WDNA ETFs invest in?

HELX leans toward sectors like Healthcare. Meanwhile, WDNA focuses on Healthcare and Non-Energy Materials.

What are the top holdings of the HELX ETF and WDNA ETF?

HELX top holdings include Guardant Health, Inc., Natera, Inc. and Krystal Biotech, Inc.. WDNA holds in its top three: Twist Bioscience Corp., Eli Lilly & Co. and Moderna, Inc..

Which ETF is more diversified: HELX or WDNA?

HELX holds 66 securities with 60.19% of its assets in the top 15. WDNA has 79 securities and a top 15 weight of 40.46%.

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