HELXvsTDNAETF Comparison
VS
Franklin Genomic Advancements ETF (HELX) belongs to the BioTech & Genomics segment. T. Rowe Price Biotech ETF (TDNA) is part of the Uncategorized Equities segment. HELX's top 3 sector exposures are Healthcare, Non-Energy Materials and Technology. In contrast, TDNA's top sector exposures are Healthcare. HELX is less expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.55% for TDNA. Run a side-by-side ETF comparison of HELX and TDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
Find out how industry players manage ETF portfolios. Discover our library of Model portfolios
HELX vs TDNA performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/29/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | HELX TDNA | +3.65%-0.08% | +18.42%n/a | +26.78%n/a | +34.48%n/a | +81.47%n/a | -13.69%n/a |
| Flows | HELX TDNA | +$2M+$568K | +$2M- | +$8M- | +$8M- | +$17M- | +$8M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | HELX TDNA | +27.48%n/a | +24.10%n/a | +21.93%n/a | +23.67%n/a |
| Max drawdown | HELX TDNA | -8.93%n/a | -17.89%n/a | -29.16%n/a | -55.27%n/a |
| Max drawdown duration | HELX TDNA | 22dn/a | 206dn/a | 458dn/a | 1822dn/a |
Trading data
HELX | TDNA | |
Last sale 10/30/2026 at 1:30 PM | $45.25 | $24.89 |
| Previous close 10/29/2026 | $46.01 | $25.17 |
| Consolidated volume 10/29/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Advertisement
Main metrics
Last update 10/30/2026 at 1:30 PM
Live
Closed
HELX | TDNA | |
|---|---|---|
| Last price | $45.25 | $24.89 |
| 1D performance | -1.65% | -1.11% |
| AuM | $36.80 M | $10.62 M |
| E/R | 0.5% | 0.55% |
Characteristics
HELX | TDNA | |
|---|---|---|
| Management strategy | Active | Active |
| Provider | Franklin Templeton | T. Rowe Price |
| Benchmark | - | - |
| N° of holdings | 66 | 86 |
| Asset class | - | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 25, 2020 | September 16, 2026 |
| ESG | No | No |
Advertisement
Exposure
Countries
HELX
USA
90.13%
Other
9.87%
TDNA
USA
88.46%
Other
11.54%
Sectors
HELX
Healthcare
97.01%
Other
2.99%
TDNA
Healthcare
98.5%
Other
1.5%
Advertisement
Diversification
HELX
Total weight of top 15 holdings out of 15
61.42%
TDNA
Total weight of top 15 holdings out of 15
37.16%
Top 15 holdings
Data as of September 30, 2026
HELX
Natera, Inc.
10.25%
Guardant Health, Inc.
9.72%
Krystal Biotech, Inc.
5.32%
Twist Bioscience Corp.
5.01%
Adaptive Biotechnologies Corp.
4.95%
Ligand Pharmaceuticals, Inc.
4.33%
BridgeBio Pharma, Inc.
2.79%
Travere Therapeutics, Inc.
2.72%
Medpace Holdings, Inc.
2.64%
Vertex Pharmaceuticals, Inc.
2.62%
Corteva, Inc.
2.33%
Eli Lilly & Co.
2.25%
Tempus AI, Inc.
2.25%
United Therapeutics Corp.
2.20%
Repligen Corp.
2.04%
TDNA
argenx SE
5.41%
Kymera Therapeutics, Inc.
4.04%
Kodiak Sciences, Inc.
2.68%
Insmed, Inc.
2.59%
Natera, Inc.
2.41%
Revolution Medicines, Inc.
2.37%
Vertex Pharmaceuticals, Inc.
2.25%
United Therapeutics Corp.
2.20%
Alnylam Pharmaceuticals, Inc.
1.98%
Dianthus Therapeutics, Inc.
1.91%
Praxis Precision Medicines, Inc.
1.91%
Moderna, Inc.
1.90%
Vaxcyte, Inc.
1.86%
Cytokinetics, Inc.
1.83%
Rhythm Pharmaceuticals, Inc.
1.81%
Frequently asked questions about HELX and TDNA
Which ETF is bigger: HELX or TDNA?
As of October 29, 2026, HELX holds $36.80 M in assets under management (AUM), while TDNA manages $10.62 M.
What sectors do the HELX and TDNA ETFs invest in?
HELX leans toward sectors like Healthcare. Meanwhile, TDNA focuses on Healthcare.
What are the top holdings of the HELX ETF and TDNA ETF?
HELX top holdings include Natera, Inc., Guardant Health, Inc. and Krystal Biotech, Inc.. TDNA holds in its top three: argenx SE, Kymera Therapeutics, Inc. and Kodiak Sciences, Inc..
Which ETF is more diversified: HELX or TDNA?
HELX holds 66 securities with 61.42% of its assets in the top 15. TDNA has 86 securities and a top 15 weight of 37.16%.
Advertisement
Advertisement
