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HELXvsPBEETF Comparison

ETF 1
HELX

Franklin Genomic Advancements ETF

This fund is part of
BioTech & Genomics
+3.75%
VS
ETF 2
PBE

Invesco Dynamic Biotechnology & Genome ETF

This fund is part of
BioTech & Genomics
+3.75%

Franklin Genomic Advancements ETF (HELX) and Invesco Dynamic Biotechnology & Genome ETF (PBE) belong to the same industry segment: BioTech & Genomics. HELX's top 3 sector exposures are Health Care, Materials and Information Technology. In contrast, PBE's top sector exposures are Health Care,  HELX is less expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.58% for PBE. HELX is down -1.22% year-to-date (YTD) with +$2M in YTD flows. PBE performs better with 3.55% YTD performance, and -$3M in YTD flows. Run a side-by-side ETF comparison of HELX and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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HELX vs PBE performance and flow charts

Performance

0246810%May 15May 22Jun 1Jun 8Jun 15

Cumulative Flows

0 M10 M20 M30 M40 M50 M60 MMay 15May 22Jun 1Jun 8Jun 15

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Historic performance and flows
Data as of 06/15/2026
1M3MYTD1Y3Y5Y
Perf.
HELX
PBE
+9.44%+5.04%
+10.46%+9.99%
-1.22%+3.55%
+30.57%+33.11%
+14.77%+35.81%
-22.60%+12.88%
Flows
HELX
PBE
-+$2M
--$3M
+$2M-$3M
+$8M-$25M
+$9M-$56M
+$14M-$45M
Volatility and drawdown
3M1Y3Y5Y
Volatility
HELX
PBE
+26.51%+19.90%
+21.11%+19.09%
+20.62%+20.14%
+23.64%+22.41%
Max drawdown
HELX
PBE
-6.54%-4.08%
-17.89%-11.70%
-29.16%-22.21%
-58.50%-34.74%
Max drawdown duration
HELX
PBE
38d16d
197d159d
458d324d
1742d1540d
Trading data

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HELX
PBE
Last sale
6/15/2026 at 2:14 PM
$35.82
$84.64
Previous close
06/15/2026
$35.45
$84.10
Consolidated volume
06/15/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of May 29, 2026
1-year trailing difference

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HELX
is actively managed and doesn’t replicate an index

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HELX
PBE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 6/15/2026 at 2:14 PM
Live
Closed
HELX
PBE
Last price
$35.82
$84.64
1D performance
+1.03%
+0.64%
AuM$23.30 M$262.42 M
E/R0.5%0.58%
Characteristics
HELX
PBE
Management strategyActivePassive
ProviderFranklin TempletonInvesco
Benchmark-Dynamic Biotech & Genome Intellidex Index
N° of holdings5030
Asset class-Equities
Trailing 12m distribution yield
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Inception dateFebruary 25, 2020June 23, 2005
ESGNoNo
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Exposure

Countries

HELX
USA
87.65%
Other
12.35%
PBE
USA
92.2%
Other
7.8%

Sectors

HELX
Health Care
89.42%
Other
10.58%
PBE
Health Care
97.78%
Other
2.22%

Diversification

HELX

Total weight of top 15 holdings out of 15

58.48%
PBE

Total weight of top 15 holdings out of 15

62.95%

Top 15 holdings

Data as of April 30, 2026
HELX
NATERA
6.86%
GUARDANT HEALTH INC
6.56%
KRYSTAL BIOTECH INC
5.67%
UTD THERAPEUT
4.48%
LIGAND PHARMACEUTICALS
4.31%
BRIDGEBIO PHARMA
4.28%
INSMED
3.80%
ASTRAZENECA
3.26%
ADAPTIVE BIOTECHNOLOGIES
3.23%
SAMSUNG BIOLOGICS CO LTD
3.14%
VERTEX PHARMACEUTICALS
2.87%
REGENERON PHARMACEUTICALS
2.60%
CORTEVA INC
2.58%
ALNYLAM PHARMACEUTICALS
2.44%
LILLY
2.39%
PBE
UTD THERAPEUT
6.20%
ILLUMINA
5.42%
REGENERON PHARMACEUTICALS
4.99%
INCYTE
4.91%
ALNYLAM PHARMACEUTICALS
4.80%
BIOGEN INC
4.80%
AMGEN-T
4.60%
GILEAD SCIENCES
4.48%
CATALYST PHARMACEUTICALS INC
3.42%
BIOCRYST PHARMACEUTICALS
3.30%
TG THERAPEUTICS
3.28%
ARROWHEAD PHARMACEUTICALS INC
3.27%
CAREDX INC/D
3.21%
PROTAGONIST THERAPEUTICS INC
3.18%
ROYALTY PHARMA
3.09%
Frequently asked questions about HELX and PBE

How have the HELX and PBE ETFs performed in 2026?

As of June 15, 2026, HELX is down -1.22% year-to-date (YTD), while PBE has returned 3.55%. That puts PBE better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or PBE?

Year-to-date, the HELX ETF saw +$2M in flows, compared to -$3M for PBE.

Which ETF is more volatile: HELX or PBE?

Over the past year, HELX had a volatility of 21.11%, while PBE experienced 19.09%.

Which ETF is bigger: HELX or PBE?

As of June 15, 2026, HELX holds $23.30 M in assets under management (AUM), while PBE manages $262.42 M.

What sectors do the HELX and PBE ETFs invest in?

HELX leans toward sectors like Health Care. Meanwhile, PBE focuses on Health Care.

What are the top holdings of the HELX ETF and PBE ETF?

HELX top holdings include NATERA, GUARDANT HEALTH INC and KRYSTAL BIOTECH INC. PBE holds in its top three: UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS.

Which ETF is more diversified: HELX or PBE?

HELX holds 60 securities with 58.48% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 62.95%.

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