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HELXvsIBBQETF Comparison

ETF 1

HELX

Franklin Genomic Advancements ETF

This fund is part of

BioTech & Genomics

-5.05%

Full HELX fund page

VS

ETF 2

IBBQ

Invesco Nasdaq Biotechnology ETF

This fund is part of

US Health Care

+0.03%

Full IBBQ fund page

Franklin Genomic Advancements ETF (HELX) belongs to the BioTech & Genomics segment. Invesco Nasdaq Biotechnology ETF (IBBQ) is part of the US Health Care segment. HELX's top 3 sector exposures are Healthcare, Non-Energy Materials and Technology. In contrast, IBBQ's top sector exposures are Healthcare and Non-Energy Materials. HELX is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.19% for IBBQ. HELX is up 24.75% year-to-date (YTD) with +$8M in YTD flows. IBBQ performs better with 28.61% YTD performance, and +$40M in YTD flows. Run a side-by-side ETF comparison of HELX and IBBQ below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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HELX vs IBBQ performance and flow charts

Performance

Cumulative Flows

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Data Services

Historic performance and flows

Data as of 10/30/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	HELX IBBQ	+1.74%+2.87%	+14.13%+11.44%	+24.75%+28.61%	+30.17%+38.59%	+78.56%+102.90%	-15.82%+49.34%
Flows	HELX IBBQ	+$2M+$11M	+$2M+$37M	+$8M+$40M	+$8M+$56M	+$17M+$75M	+$8M+$53M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	HELX IBBQ	+27.48%+25.69%	+24.12%+22.54%	+21.94%+21.19%	+23.68%+22.20%
Max drawdown	HELX IBBQ	-8.93%-8.58%	-17.89%-8.58%	-29.16%-23.78%	-55.27%-34.86%
Max drawdown duration	HELX IBBQ	22d72d	206d72d	458d375d	1823d1429d

Trading data

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	HELX	IBBQ
Last sale 10/30/2026 at 1:30 PM	$45.25	$36.17
Previous close 10/29/2026	$46.01	$36.17
Consolidated volume 10/29/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of September 30, 2026

1-year trailing difference

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HELX

is actively managed and doesn’t replicate an index

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	HELX	IBBQ
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 10/30/2026 at 1:30 PM

Live

Closed

	HELX	IBBQ
Last price	$45.25	$36.17
1D performance	-1.65%	-0.01%
AuM	$36.21 M	$122.25 M
E/R	0.5%	0.19%

Characteristics

	HELX	IBBQ
Management strategy	Active	Passive
Provider	Franklin Templeton	Invesco
Benchmark	-	NASDAQ Biotechnology Index
N° of holdings	66	245
Asset class	-	Equities
Trailing 12m distribution yield	Join	Join
Inception date	February 25, 2020	June 9, 2021
ESG	No	No

More HELX data on Trackinsight

More IBBQ data on Trackinsight

Exposure

Countries

HELX

USA

90.13%

Other

9.87%

IBBQ

USA

88.6%

Other

11.4%

Sectors

HELX

Healthcare

97.01%

Other

2.99%

IBBQ

Healthcare

99.99%

Other

0.01%

Diversification

HELX

Total weight of top 15 holdings out of 15

61.42%

IBBQ

Total weight of top 15 holdings out of 15

54.02%

Top 15 holdings

Data as of September 30, 2026

HELX

Natera, Inc.

10.25%

Guardant Health, Inc.

9.72%

Krystal Biotech, Inc.

5.32%

Twist Bioscience Corp.

5.01%

Adaptive Biotechnologies Corp.

4.95%

Ligand Pharmaceuticals, Inc.

4.33%

BridgeBio Pharma, Inc.

2.79%

Travere Therapeutics, Inc.

2.72%

Medpace Holdings, Inc.

2.64%

Vertex Pharmaceuticals, Inc.

2.62%

Corteva, Inc.

2.33%

Eli Lilly & Co.

2.25%

Tempus AI, Inc.

2.25%

United Therapeutics Corp.

2.20%

Repligen Corp.

2.04%

IBBQ

Gilead Sciences, Inc.

8.32%

Amgen, Inc.

7.78%

Vertex Pharmaceuticals, Inc.

7.75%

Moderna, Inc.

5.16%

Regeneron Pharmaceuticals, Inc.

4.98%

Revolution Medicines, Inc.

2.83%

Illumina, Inc.

2.69%

Alnylam Pharmaceuticals, Inc.

2.24%

Biogen, Inc.

2.21%

Roivant Sciences Ltd.

1.75%

argenx SE

1.74%

Royalty Pharma Plc

1.70%

Insmed, Inc.

1.68%

Incyte Corp.

1.66%

Guardant Health, Inc.

1.56%

Frequently asked questions about HELX and IBBQ

How have the HELX and IBBQ ETFs performed in 2026?

As of October 30, 2026, HELX is up 24.75% year-to-date (YTD), while IBBQ has returned 28.61%. That puts IBBQ better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or IBBQ?

Year-to-date, the HELX ETF saw +$8M in flows, compared to +$40M for IBBQ.

Which ETF is more volatile: HELX or IBBQ?

Over the past year, HELX had a volatility of 24.12%, while IBBQ experienced 22.54%.

Which ETF is bigger: HELX or IBBQ?

As of October 30, 2026, HELX holds $36.21 M in assets under management (AUM), while IBBQ manages $122.25 M.

What sectors do the HELX and IBBQ ETFs invest in?

HELX leans toward sectors like Healthcare. Meanwhile, IBBQ focuses on Healthcare.

What are the top holdings of the HELX ETF and IBBQ ETF?

HELX top holdings include Natera, Inc., Guardant Health, Inc. and Krystal Biotech, Inc.. IBBQ holds in its top three: Gilead Sciences, Inc., Amgen, Inc. and Vertex Pharmaceuticals, Inc..

HELXvsIBBQETF Comparison

Franklin Genomic Advancements ETF

Invesco Nasdaq Biotechnology ETF

HELX vs IBBQ performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the HELX and IBBQ ETFs performed in 2026?

As of October 30, 2026, HELX is up 24.75% year-to-date (YTD), while IBBQ has returned 28.61%. That puts IBBQ better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or IBBQ?

Year-to-date, the HELX ETF saw +$8M in flows, compared to +$40M for IBBQ.

Which ETF is more volatile: HELX or IBBQ?

Over the past year, HELX had a volatility of 24.12%, while IBBQ experienced 22.54%.

Which ETF is bigger: HELX or IBBQ?

As of October 30, 2026, HELX holds $36.21 M in assets under management (AUM), while IBBQ manages $122.25 M.

What sectors do the HELX and IBBQ ETFs invest in?

HELX leans toward sectors like Healthcare. Meanwhile, IBBQ focuses on Healthcare.

What are the top holdings of the HELX ETF and IBBQ ETF?

HELX top holdings include Natera, Inc., Guardant Health, Inc. and Krystal Biotech, Inc.. IBBQ holds in its top three: Gilead Sciences, Inc., Amgen, Inc. and Vertex Pharmaceuticals, Inc..

Which ETF is more diversified: HELX or IBBQ?

HELX holds 66 securities with 61.42% of its assets in the top 15. IBBQ has 245 securities and a top 15 weight of 54.02%.

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