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HELXvsGNOMETF Comparison

ETF 1
HELX

Franklin Genomic Advancements ETF

This fund is part of
BioTech & Genomics
-0.67%
VS
ETF 2
GNOM

Global X Genomics & Biotechnology ETF - USD

This fund is part of
BioTech & Genomics
-0.67%

Franklin Genomic Advancements ETF (HELX) and Global X Genomics & Biotechnology ETF - USD (GNOM) belong to the same industry segment: BioTech & Genomics. HELX's top 3 sector exposures are Health Care, Materials and Information Technology. In contrast, GNOM's top sector exposures are Health Care,  Both HELX and GNOM have the same Total Expense Ratio (TER) of 0.5%. HELX is down -7.69% year-to-date (YTD) with +$2M in YTD flows. GNOM performs better with 0.74% YTD performance, and -$602K in YTD flows. Run a side-by-side ETF comparison of HELX and GNOM below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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HELX vs GNOM performance and flow charts

Performance

0510%Mar 24Mar 31Apr 8Apr 15Apr 22

Cumulative Flows

-800,000-600,000-400,000-200,0000Mar 24Mar 31Apr 8Apr 15Apr 22

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Historic performance and flows
Data as of 04/24/2026
1M3MYTD1Y3Y5Y
Perf.
HELX
GNOM
+5.41%+7.67%
-10.90%-7.03%
-7.69%+0.74%
+23.56%+41.51%
+9.47%-6.56%
-30.03%-50.60%
Flows
HELX
GNOM
--$829K
-+$1M
+$2M-$602K
+$8M-$14M
+$9M-$120M
+$14M+$1M
Volatility and drawdown
3M1Y3Y5Y
Volatility
HELX
GNOM
+24.83%+28.47%
+20.80%+27.16%
+20.28%+28.79%
+23.68%+33.22%
Max drawdown
HELX
GNOM
-16.86%-16.08%
-17.89%-18.16%
-29.16%-46.50%
-58.50%-72.17%
Max drawdown duration
HELX
GNOM
88d88d
145d92d
458d1075d
1690d1758d
Trading data

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HELX
GNOM
Last sale
4/27/2026 at 1:30 PM
$33.63
$45.55
Previous close
04/24/2026
$33.53
$45.97
Consolidated volume
04/24/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of March 31, 2026
1-year trailing difference

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HELX
is actively managed and doesn’t replicate an index

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HELX
GNOM
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 4/27/2026 at 1:30 PM
Live
Closed
HELX
GNOM
Last price
$33.63
$45.55
1D performance
+0.31%
-0.92%
AuM$21.77 M$51.60 M
E/R0.5%0.5%
Characteristics
HELX
GNOM
Management strategyActivePassive
ProviderFranklin TempletonGlobal X
Benchmark-Solactive Genomics Index
N° of holdings5145
Asset class-Equities
Trailing 12m distribution yield
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Inception dateFebruary 25, 2020April 5, 2019
ESGNoNo
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Exposure

Countries

HELX
USA
87.6%
Other
12.4%
GNOM
USA
87.57%
Other
12.43%

Sectors

HELX
Health Care
89.74%
Other
10.26%
GNOM
Health Care
88.49%
Other
11.51%
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Diversification

HELX

Total weight of top 15 holdings out of 15

60.42%
GNOM

Total weight of top 15 holdings out of 15

66.21%

Top 15 holdings

Data as of March 31, 2026
HELX
NATERA
6.89%
GUARDANT HEALTH INC
6.82%
KRYSTAL BIOTECH INC
5.46%
UTD THERAPEUT
4.40%
BRIDGEBIO PHARMA
4.36%
INSMED
4.31%
LIGAND PHARMACEUTICALS
3.80%
SAMSUNG BIOLOGICS CO LTD
3.37%
ADAPTIVE BIOTECHNOLOGIES
3.32%
ASTRAZENECA
3.24%
VERTEX PHARMACEUTICALS
3.20%
MEDPACE HOLDINGS INC
3.05%
CORTEVA INC
2.81%
ALNYLAM PHARMACEUTICALS
2.71%
REGENERON PHARMACEUTICALS
2.67%
GNOM
MODERNA INC
8.48%
ARROWHEAD PHARMACEUTICALS INC
6.21%
US74006W2070
6.13%
ILLUMINA
5.52%
GUARDANT HEALTH INC
5.18%
VERTEX PHARMACEUTICALS
4.61%
BIOMARIN PHARMACEUTICAL
4.59%
NATERA
4.21%
BIO-TECHNE CORP
3.64%
BIONTECH SE ADR
3.58%
CRISPR THERAPEUTICS
3.08%
BRISTOL-MYERS SQUIBB
3.05%
ALNYLAM PHARMACEUTICALS
2.85%
TWIST BIOSCIENCE CORP
2.54%
ASTRAZENECA
2.53%
Frequently asked questions about HELX and GNOM

How have the HELX and GNOM ETFs performed in 2026?

As of April 24, 2026, HELX is down -7.69% year-to-date (YTD), while GNOM has returned 0.74%. That puts GNOM better performer ahead so far this year.

Which ETF is attracting more investor money: HELX or GNOM?

Year-to-date, the HELX ETF saw +$2M in flows, compared to -$602K for GNOM.

Which ETF is more volatile: HELX or GNOM?

Over the past year, HELX had a volatility of 20.8%, while GNOM experienced 27.16%.

Which ETF is bigger: HELX or GNOM?

As of April 24, 2026, HELX holds $21.77 M in assets under management (AUM), while GNOM manages $51.60 M.

What sectors do the HELX and GNOM ETFs invest in?

HELX leans toward sectors like Health Care. Meanwhile, GNOM focuses on Health Care.

What are the top holdings of the HELX ETF and GNOM ETF?

HELX top holdings include NATERA, GUARDANT HEALTH INC and KRYSTAL BIOTECH INC. GNOM holds in its top three: MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070.

Which ETF is more diversified: HELX or GNOM?

HELX holds 60 securities with 60.42% of its assets in the top 15. GNOM has 47 securities and a top 15 weight of 66.21%.

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