HELXvsFMEDETF Comparison
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Franklin Genomic Advancements ETF (HELX) belongs to the BioTech & Genomics segment. Fidelity Disruptive Medicine ETF (FMED) is part of the Multiple Trends segment. HELX's top 3 sector exposures are Healthcare, Non-Energy Materials and Technology. In contrast, FMED's top sector exposures are Healthcare. Both HELX and FMED have the same Total Expense Ratio (TER) of 0.5%. HELX is up 12.93% year-to-date (YTD) with +$6M in YTD flows. FMED performs better with 14.16% YTD performance, and -$17M in YTD flows. Run a side-by-side ETF comparison of HELX and FMED below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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HELX vs FMED performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | HELX FMED | -1.05%+2.35% | +15.09%+21.18% | +12.93%+14.16% | +33.15%+23.99% | +37.37%+31.64% | -26.59%n/a |
| Flows | HELX FMED | -- | +$4M- | +$6M-$17M | +$8M-$14M | +$15M-$3M | +$4M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | HELX FMED | +24.44%+24.07% | +22.84%+21.00% | +21.42%+19.21% | +23.54%n/a |
| Max drawdown | HELX FMED | -6.59%-7.15% | -17.89%-17.78% | -29.16%-19.20% | -58.16%n/a |
| Max drawdown duration | HELX FMED | 28d29d | 206d212d | 458d267d | 1814dn/a |
Trading data
HELX | FMED | |
Last sale 9/14/2026 at 1:30 PM | $41.56 | |
| Previous close 09/11/2026 | $40.99 | |
| Consolidated volume 09/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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Main metrics
Last update 9/14/2026 at 1:30 PM
Live
Closed
HELX | FMED | |
|---|---|---|
| Last price | $41.56 | – |
| 1D performance | +1.40% | – |
| AuM | $30.73 M | $50.22 M |
| E/R | 0.5% | 0.5% |
Characteristics
HELX | FMED | |
|---|---|---|
| Management strategy | Active | Active |
| Provider | Franklin Templeton | Fidelity |
| Benchmark | - | - |
| N° of holdings | 66 | 74 |
| Asset class | - | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 25, 2020 | June 12, 2023 |
| ESG | No | No |
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Exposure
Countries
HELX
USA
86.99%
Other
13.01%
FMED
USA
83.4%
Other
16.6%
Sectors
HELX
Healthcare
96.35%
Other
3.65%
FMED
Healthcare
100%
Other
0%
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Diversification
HELX
Total weight of top 15 holdings out of 15
60.19%
FMED
Total weight of top 15 holdings out of 15
43.09%
Top 15 holdings
Data as of July 31, 2026
HELX
Guardant Health, Inc.
9.10%
Natera, Inc.
7.31%
Krystal Biotech, Inc.
6.17%
Ligand Pharmaceuticals, Inc.
4.48%
Adaptive Biotechnologies Corp.
4.33%
BridgeBio Pharma, Inc.
4.08%
United Therapeutics Corp.
3.52%
Eli Lilly & Co.
3.04%
Vertex Pharmaceuticals, Inc.
2.73%
SAMSUNG BIOLOGICS Co., Ltd.
2.72%
Travere Therapeutics, Inc.
2.67%
Corteva, Inc.
2.65%
AstraZeneca PLC
2.49%
Twist Bioscience Corp.
2.47%
Medpace Holdings, Inc.
2.44%
FMED
10X Genomics, Inc.
4.48%
Thermo Fisher Scientific, Inc.
3.98%
Danaher Corp.
3.86%
Lifestance Health Group, Inc.
3.15%
Alnylam Pharmaceuticals, Inc.
3.10%
argenx SE
2.99%
Cogent Biosciences, Inc.
2.98%
Revolution Medicines, Inc.
2.85%
Illumina, Inc.
2.62%
Intuitive Surgical, Inc.
2.34%
Kymera Therapeutics, Inc.
2.29%
UnitedHealth Group, Inc.
2.24%
Ascendis Pharma A/S
2.12%
Kiniksa Pharmaceuticals International Plc
2.06%
UCB SA
2.03%
Frequently asked questions about HELX and FMED
How have the HELX and FMED ETFs performed in 2026?
As of September 11, 2026, HELX is up 12.93% year-to-date (YTD), while FMED has returned 14.16%. That puts FMED better performer ahead so far this year.
Which ETF is attracting more investor money: HELX or FMED?
Year-to-date, the HELX ETF saw +$6M in flows, compared to -$17M for FMED.
Which ETF is more volatile: HELX or FMED?
Over the past year, HELX had a volatility of 22.84%, while FMED experienced 21%.
Which ETF is bigger: HELX or FMED?
As of September 11, 2026, HELX holds $30.73 M in assets under management (AUM), while FMED manages $50.22 M.
What sectors do the HELX and FMED ETFs invest in?
HELX leans toward sectors like Healthcare. Meanwhile, FMED focuses on Healthcare.
What are the top holdings of the HELX ETF and FMED ETF?
HELX top holdings include Guardant Health, Inc., Natera, Inc. and Krystal Biotech, Inc.. FMED holds in its top three: 10X Genomics, Inc., Thermo Fisher Scientific, Inc. and Danaher Corp..
Which ETF is more diversified: HELX or FMED?
HELX holds 66 securities with 60.19% of its assets in the top 15. FMED has 74 securities and a top 15 weight of 43.09%.
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