HELXvsFMEDETF Comparison
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Franklin Genomic Advancements ETF (HELX) belongs to the BioTech & Genomics segment. Fidelity Disruptive Medicine ETF (FMED) is part of the Multiple Trends segment. HELX's top 3 sector exposures are Healthcare, Non-Energy Materials and Technology. In contrast, FMED's top sector exposures are Healthcare. Both HELX and FMED have the same Total Expense Ratio (TER) of 0.5%. HELX is up 26.78% year-to-date (YTD) with +$8M in YTD flows. FMED performs worse with 23.62% YTD performance, and -$17M in YTD flows. Run a side-by-side ETF comparison of HELX and FMED below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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HELX vs FMED performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/29/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | HELX FMED | +3.65%+3.64% | +18.42%+17.62% | +26.78%+23.62% | +34.48%+26.77% | +81.47%+68.44% | -13.69%n/a |
| Flows | HELX FMED | +$2M- | +$2M- | +$8M-$17M | +$8M-$14M | +$17M-$12M | +$8M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | HELX FMED | +27.48%+27.55% | +24.10%+22.64% | +21.93%+19.74% | +23.67%n/a |
| Max drawdown | HELX FMED | -8.93%-7.63% | -17.89%-17.78% | -29.16%-19.20% | -55.27%n/a |
| Max drawdown duration | HELX FMED | 22d69d | 206d212d | 458d267d | 1822dn/a |
Trading data
HELX | FMED | |
Last sale 10/30/2026 at 1:30 PM | $45.25 | |
| Previous close 10/29/2026 | $46.01 | |
| Consolidated volume 10/29/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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Main metrics
Last update 10/30/2026 at 1:30 PM
Live
Closed
HELX | FMED | |
|---|---|---|
| Last price | $45.25 | – |
| 1D performance | -1.65% | – |
| AuM | $36.80 M | $54.39 M |
| E/R | 0.5% | 0.5% |
Characteristics
HELX | FMED | |
|---|---|---|
| Management strategy | Active | Active |
| Provider | Franklin Templeton | Fidelity |
| Benchmark | - | - |
| N° of holdings | 66 | 71 |
| Asset class | - | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 25, 2020 | June 12, 2023 |
| ESG | No | No |
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Exposure
Countries
HELX
USA
90.13%
Other
9.87%
FMED
USA
84.97%
Other
15.03%
Sectors
HELX
Healthcare
97.01%
Other
2.99%
FMED
Healthcare
99.49%
Other
0.51%
Diversification
HELX
Total weight of top 15 holdings out of 15
61.42%
FMED
Total weight of top 15 holdings out of 15
47.18%
Top 15 holdings
Data as of September 30, 2026
HELX
Natera, Inc.
10.25%
Guardant Health, Inc.
9.72%
Krystal Biotech, Inc.
5.32%
Twist Bioscience Corp.
5.01%
Adaptive Biotechnologies Corp.
4.95%
Ligand Pharmaceuticals, Inc.
4.33%
BridgeBio Pharma, Inc.
2.79%
Travere Therapeutics, Inc.
2.72%
Medpace Holdings, Inc.
2.64%
Vertex Pharmaceuticals, Inc.
2.62%
Corteva, Inc.
2.33%
Eli Lilly & Co.
2.25%
Tempus AI, Inc.
2.25%
United Therapeutics Corp.
2.20%
Repligen Corp.
2.04%
FMED
10X Genomics, Inc.
5.82%
Natera, Inc.
4.47%
Thermo Fisher Scientific, Inc.
4.19%
Danaher Corp.
3.92%
Illumina, Inc.
3.56%
argenx SE
2.96%
Lifestance Health Group, Inc.
2.87%
Revolution Medicines, Inc.
2.86%
Sartorius Stedim Biotech SA
2.72%
Moderna, Inc.
2.62%
Alnylam Pharmaceuticals, Inc.
2.48%
HeartFlow, Inc.
2.39%
Intuitive Surgical, Inc.
2.20%
Cogent Biosciences, Inc.
2.13%
Caris Life Sciences, Inc.
1.99%
Frequently asked questions about HELX and FMED
How have the HELX and FMED ETFs performed in 2026?
As of October 29, 2026, HELX is up 26.78% year-to-date (YTD), while FMED has returned 23.62%. That puts HELX better performer ahead so far this year.
Which ETF is attracting more investor money: HELX or FMED?
Year-to-date, the HELX ETF saw +$8M in flows, compared to -$17M for FMED.
Which ETF is more volatile: HELX or FMED?
Over the past year, HELX had a volatility of 24.1%, while FMED experienced 22.64%.
Which ETF is bigger: HELX or FMED?
As of October 29, 2026, HELX holds $36.80 M in assets under management (AUM), while FMED manages $54.39 M.
What sectors do the HELX and FMED ETFs invest in?
HELX leans toward sectors like Healthcare. Meanwhile, FMED focuses on Healthcare.
What are the top holdings of the HELX ETF and FMED ETF?
HELX top holdings include Natera, Inc., Guardant Health, Inc. and Krystal Biotech, Inc.. FMED holds in its top three: 10X Genomics, Inc., Natera, Inc. and Thermo Fisher Scientific, Inc..
Which ETF is more diversified: HELX or FMED?
HELX holds 66 securities with 61.42% of its assets in the top 15. FMED has 71 securities and a top 15 weight of 47.18%.
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