HELXvsBBPETF Comparison
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Franklin Genomic Advancements ETF (HELX) belongs to the BioTech & Genomics segment. Virtus LifeSci Biotech Products ETF (BBP) is part of the Tomorrow's Treatments segment. HELX's top 3 sector exposures are Healthcare, Non-Energy Materials and Technology. In contrast, BBP's top sector exposures are Healthcare. HELX is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.34% for BBP. HELX is up 12.93% year-to-date (YTD) with +$6M in YTD flows. BBP performs better with 29.59% YTD performance, and +$61M in YTD flows. Run a side-by-side ETF comparison of HELX and BBP below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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HELX vs BBP performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | HELX BBP | -1.05%+1.58% | +15.09%+19.06% | +12.93%+29.59% | +33.15%+46.60% | +37.37%+94.97% | -26.59%+99.54% |
| Flows | HELX BBP | -+$16M | +$4M+$31M | +$6M+$61M | +$8M+$72M | +$15M+$78M | +$4M+$71M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | HELX BBP | +24.44%+25.64% | +22.84%+25.15% | +21.42%+24.71% | +23.54%+26.61% |
| Max drawdown | HELX BBP | -6.59%-9.34% | -17.89%-9.59% | -29.16%-25.54% | -58.16%-37.61% |
| Max drawdown duration | HELX BBP | 28d39d | 206d48d | 458d292d | 1814d586d |
Trading data
HELX | BBP | |
Last sale 9/14/2026 at 1:30 PM | $41.56 | $104.42 |
| Previous close 09/11/2026 | $40.99 | $103.46 |
| Consolidated volume 09/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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HELX
is actively managed and doesn’t replicate an indexHELX | BBP | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/14/2026 at 1:30 PM
Live
Closed
HELX | BBP | |
|---|---|---|
| Last price | $41.56 | $104.42 |
| 1D performance | +1.40% | +0.93% |
| AuM | $30.73 M | $124.03 M |
| E/R | 0.5% | 0.34% |
Characteristics
HELX | BBP | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | Franklin Templeton | VIRTUS Investment Partners |
| Benchmark | - | LifeSci Biotechnology Products Index |
| N° of holdings | 66 | 66 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 25, 2020 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
HELX
USA
86.99%
Other
13.01%
BBP
USA
86.5%
Other
13.5%
Sectors
HELX
Healthcare
96.35%
Other
3.65%
BBP
Healthcare
98.2%
Other
1.8%
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Diversification
HELX
Total weight of top 15 holdings out of 15
60.19%
BBP
Total weight of top 15 holdings out of 15
26.78%
Top 15 holdings
Data as of July 31, 2026
HELX
Guardant Health, Inc.
9.10%
Natera, Inc.
7.31%
Krystal Biotech, Inc.
6.17%
Ligand Pharmaceuticals, Inc.
4.48%
Adaptive Biotechnologies Corp.
4.33%
BridgeBio Pharma, Inc.
4.08%
United Therapeutics Corp.
3.52%
Eli Lilly & Co.
3.04%
Vertex Pharmaceuticals, Inc.
2.73%
SAMSUNG BIOLOGICS Co., Ltd.
2.72%
Travere Therapeutics, Inc.
2.67%
Corteva, Inc.
2.65%
AstraZeneca PLC
2.49%
Twist Bioscience Corp.
2.47%
Medpace Holdings, Inc.
2.44%
BBP
Crinetics Pharmaceuticals, Inc.
3.24%
Verastem, Inc.
1.98%
Nuvation Bio, Inc.
1.80%
Omeros Corp.
1.73%
Geron Corp.
1.72%
BridgeBio Pharma, Inc.
1.68%
Agios Pharmaceuticals, Inc.
1.67%
Protagonist Therapeutics, Inc.
1.65%
BeOne Medicines Ltd.
1.64%
Kiniksa Pharmaceuticals International Plc
1.63%
Precigen, Inc.
1.62%
Xeris Biopharma Holdings, Inc.
1.61%
ACADIA Pharmaceuticals, Inc.
1.60%
Iovance Biotherapeutics, Inc.
1.60%
Rhythm Pharmaceuticals, Inc.
1.60%
Frequently asked questions about HELX and BBP
How have the HELX and BBP ETFs performed in 2026?
As of September 11, 2026, HELX is up 12.93% year-to-date (YTD), while BBP has returned 29.59%. That puts BBP better performer ahead so far this year.
Which ETF is attracting more investor money: HELX or BBP?
Year-to-date, the HELX ETF saw +$6M in flows, compared to +$61M for BBP.
Which ETF is more volatile: HELX or BBP?
Over the past year, HELX had a volatility of 22.84%, while BBP experienced 25.15%.
Which ETF is bigger: HELX or BBP?
As of September 11, 2026, HELX holds $30.73 M in assets under management (AUM), while BBP manages $124.03 M.
What sectors do the HELX and BBP ETFs invest in?
HELX leans toward sectors like Healthcare. Meanwhile, BBP focuses on Healthcare.
What are the top holdings of the HELX ETF and BBP ETF?
HELX top holdings include Guardant Health, Inc., Natera, Inc. and Krystal Biotech, Inc.. BBP holds in its top three: Crinetics Pharmaceuticals, Inc., Verastem, Inc. and Nuvation Bio, Inc..
Which ETF is more diversified: HELX or BBP?
HELX holds 66 securities with 60.19% of its assets in the top 15. BBP has 66 securities and a top 15 weight of 26.78%.
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