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GNOMvsXHSETF Comparison

ETF 1
GNOM

Global X Genomics & Biotechnology ETF - USD

This fund is part of
BioTech & Genomics
-0.87%
Full GNOM fund page
VS
ETF 2
XHS

SPDR S&P Health Care Services ETF

This fund is part of
US Health Care
-2%
Full XHS fund page

Global X Genomics & Biotechnology ETF - USD (GNOM) belongs to the BioTech & Genomics segment. SPDR S&P Health Care Services ETF (XHS) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Health Care. GNOM is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.35% for XHS. GNOM is down -4.2% year-to-date (YTD) with -$2M in YTD flows. XHS performs better with -3.54% YTD performance, and +$6M in YTD flows. Run a side-by-side ETF comparison of GNOM and XHS below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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GNOM vs XHS performance and flow charts

Performance

-4.0-2.00.02.04.06.0%Feb 12Feb 20Feb 27Mar 6

Cumulative Flows

-8 M-6 M-4 M-2 M0 MFeb 12Feb 20Feb 27Mar 6

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Historic performance and flows
Data as of 03/12/2026
1M3MYTD1Y3Y5Y
Perf.
GNOM
XHS
-4.14%-3.48%
-5.72%-5.76%
-4.20%-3.54%
+23.30%+9.47%
-9.06%+24.45%
-52.80%-2.70%
Flows
GNOM
XHS
--$8M
-$4M+$2M
-$2M+$6M
-$19M-$3M
-$115M-$34M
+$11M-$34M
Volatility and drawdown
3M1Y3Y5Y
Volatility
GNOM
XHS
+24.30%+17.81%
+30.21%+19.28%
+28.57%+18.17%
+33.50%+21.14%
Max drawdown
GNOM
XHS
-13.77%-7.72%
-22.14%-12.54%
-46.50%-17.78%
-72.17%-32.53%
Max drawdown duration
GNOM
XHS
49d65d
113d128d
1032d362d
1715d1718d
Trading data

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GNOM
XHS
Last sale
3/12/2026 at 7:16 PM
$43.93
$103.05
Previous close
03/12/2026
$45.00
$104.90
Consolidated volume
03/12/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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GNOM
XHS
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/12/2026 at 7:16 PM
Live
Closed
GNOM
XHS
Last price
$43.93
$103.05
1D performance
-2.38%
-1.76%
AuM$47.76 M$85.58 M
E/R0.5%0.35%
Characteristics
GNOM
XHS
Management strategyPassivePassive
ProviderGlobal XSPDR
BenchmarkSolactive Genomics IndexS&P Health Care Services Select Industry Index
N° of holdings4652
Asset classEquitiesEquities
Trailing 12m distribution yield
Join
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Inception dateApril 5, 2019September 28, 2011
ESGNoNo
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Exposure

Countries

GNOM
USA
87.04%
Other
12.96%
XHS
USA
99.96%
Other
0.04%

Sectors

GNOM
Health Care
87.95%
Other
12.05%
XHS
Health Care
87.38%
Other
12.62%
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Diversification

GNOM

Total weight of top 15 holdings out of 15

63.95%
XHS

Total weight of top 15 holdings out of 15

33.22%

Top 15 holdings

Data as of January 31, 2026
GNOM
MODERNA INC
6.79%
ARROWHEAD PHARMACEUTICALS INC
6.14%
US74006W2070
5.75%
ILLUMINA
5.64%
GUARDANT HEALTH INC
5.47%
NATERA
4.30%
VERTEX PHARMACEUTICALS
4.08%
BIONTECH SE ADR
4.04%
BIOMARIN PHARMACEUTICAL
3.93%
AVIDITY BIOSCIENCES
3.73%
BIO-TECHNE CORP
3.69%
CRISPR THERAPEUTICS
3.05%
ALNYLAM PHARMACEUTICALS
2.58%
VERACYTE INC/D
2.50%
BRISTOL-MYERS SQUIBB
2.28%
XHS
BROOKDALE SENIOR LIVING
2.87%
ALIGNMENT HEALTHCARE
2.39%
US20603L1026
2.27%
CENTENE
2.25%
MOLINA HLTHCRE
2.24%
US10950A1060
2.24%
GUARDANT HEALTH INC
2.23%
CARDINAL HEALTH
2.17%
AMERISOURCEBERGEN
2.11%
CIGNA
2.09%
HCA HEALTHCARE
2.09%
QUEST DIAGNOSTICS
2.09%
US5049221055
2.08%
OPTION CARE HEALTH INC
2.06%
MCKESSON
2.04%
Frequently asked questions about GNOM and XHS

How have the GNOM and XHS ETFs performed in 2026?

As of March 12, 2026, GNOM is down -4.2% year-to-date (YTD), while XHS has lost -3.54%. That puts XHS better performer ahead so far this year.

Which ETF is attracting more investor money: GNOM or XHS?

Year-to-date, the GNOM ETF saw -$2M in flows, compared to +$6M for XHS.

Which ETF is more volatile: GNOM or XHS?

Over the past year, GNOM had a volatility of 30.21%, while XHS experienced 19.28%.

Which ETF is bigger: GNOM or XHS?

As of March 12, 2026, GNOM holds $47.76 M in assets under management (AUM), while XHS manages $85.58 M.

What sectors do the GNOM and XHS ETFs invest in?

GNOM leans toward sectors like Health Care. Meanwhile, XHS focuses on Health Care.

What are the top holdings of the GNOM ETF and XHS ETF?

GNOM top holdings include MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070. XHS holds in its top three: BROOKDALE SENIOR LIVING, ALIGNMENT HEALTHCARE and US20603L1026.

Which ETF is more diversified: GNOM or XHS?

GNOM holds 48 securities with 63.95% of its assets in the top 15. XHS has 59 securities and a top 15 weight of 33.22%.

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