GNOMvsXHSETF Comparison
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Global X Genomics & Biotechnology ETF (GNOM) belongs to the BioTech & Genomics segment. State Street SPDR S&P Health Care Services ETF (XHS) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Health Care. GNOM is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.35% for XHS. GNOM is up 10.2% year-to-date (YTD) with +$4M in YTD flows. XHS performs better with 14.46% YTD performance, and +$16M in YTD flows. Run a side-by-side ETF comparison of GNOM and XHS below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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GNOM vs XHS performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/15/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | GNOM XHS | +13.00%+8.48% | +14.76%+18.07% | +10.20%+14.46% | +54.07%+26.36% | -1.12%+35.25% | -44.29%+7.99% |
| Flows | GNOM XHS | +$4M+$4M | +$6M+$10M | +$4M+$16M | -$4M+$3M | -$104M-$21M | +$5M-$72M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | GNOM XHS | +31.68%+16.76% | +26.60%+18.00% | +28.96%+17.92% | +33.27%+21.22% |
| Max drawdown | GNOM XHS | -7.88%-5.61% | -18.16%-11.97% | -45.66%-17.78% | -72.17%-32.53% |
| Max drawdown duration | GNOM XHS | 36d21d | 144d121d | 1096d362d | 1810d1786d |
Trading data
GNOM | XHS | |
Last sale 6/16/2026 at 2:04 PM | $50.22 | $122.14 |
| Previous close 06/15/2026 | $50.10 | $122.08 |
| Consolidated volume 06/15/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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GNOM | XHS | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/16/2026 at 2:04 PM
Live
Closed
GNOM | XHS | |
|---|---|---|
| Last price | $50.22 | $122.14 |
| 1D performance | +0.24% | +0.05% |
| AuM | $60.96 M | $112.51 M |
| E/R | 0.5% | 0.35% |
Characteristics
GNOM | XHS | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Global X | State Street Investment Management |
| Benchmark | Solactive Genomics Index | S&P Health Care Services Select Industry Index |
| N° of holdings | 45 | 51 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | April 5, 2019 | September 28, 2011 |
| ESG | No | No |
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Exposure
Countries
GNOM
USA
88%
Other
12%
XHS
USA
99.91%
Other
0.09%
Sectors
GNOM
Health Care
88.52%
Other
11.48%
XHS
Health Care
86.95%
Other
13.05%
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Diversification
GNOM
Total weight of top 15 holdings out of 15
66.44%
XHS
Total weight of top 15 holdings out of 15
33.75%
Top 15 holdings
Data as of April 30, 2026
GNOM
MODERNA INC
7.59%
ARROWHEAD PHARMACEUTICALS INC
7.18%
US74006W2070
6.77%
ILLUMINA
5.19%
GUARDANT HEALTH INC
4.73%
BIOMARIN PHARMACEUTICAL
4.29%
VERTEX PHARMACEUTICALS
4.16%
NATERA
4.14%
BIONTECH SE ADR
4.03%
BIO-TECHNE CORP
3.44%
CRISPR THERAPEUTICS
3.32%
TWIST BIOSCIENCE CORP
3.14%
LEGEND BIOTECH
2.91%
NL0015002SN0
2.77%
BRISTOL-MYERS SQUIBB
2.77%
XHS
CENTENE
2.76%
HUMANA
2.55%
MOLINA HLTHCRE
2.44%
ELEVANCE HEALTH INC
2.39%
UNITEDHEALTH GRP
2.39%
ALIGNMENT HEALTHCARE
2.31%
CLOVER HEALTH INV CORP
2.28%
APOLLO MEDICAL HOLDINGS INC
2.25%
US10950A1060
2.14%
MEDNAX
2.10%
PRIVIA HEALTH GROUP
2.07%
CIGNA
2.05%
CVS HEALTH CORP
2.03%
CORVEL
2.00%
ACADIA HEALTHCARE COMPANY
2.00%
Frequently asked questions about GNOM and XHS
How have the GNOM and XHS ETFs performed in 2026?
As of June 15, 2026, GNOM is up 10.2% year-to-date (YTD), while XHS has returned 14.46%. That puts XHS better performer ahead so far this year.
Which ETF is attracting more investor money: GNOM or XHS?
Year-to-date, the GNOM ETF saw +$4M in flows, compared to +$16M for XHS.
Which ETF is more volatile: GNOM or XHS?
Over the past year, GNOM had a volatility of 26.6%, while XHS experienced 18%.
Which ETF is bigger: GNOM or XHS?
As of June 15, 2026, GNOM holds $60.96 M in assets under management (AUM), while XHS manages $112.51 M.
What sectors do the GNOM and XHS ETFs invest in?
GNOM leans toward sectors like Health Care. Meanwhile, XHS focuses on Health Care.
What are the top holdings of the GNOM ETF and XHS ETF?
GNOM top holdings include MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070. XHS holds in its top three: CENTENE, HUMANA and MOLINA HLTHCRE.
Which ETF is more diversified: GNOM or XHS?
GNOM holds 49 securities with 66.44% of its assets in the top 15. XHS has 58 securities and a top 15 weight of 33.75%.
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