GNOMvsXHEETF Comparison
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Global X Genomics & Biotechnology ETF - USD (GNOM) belongs to the BioTech & Genomics segment. State Street SPDR S&P Health Care Equipment ETF (XHE) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Health Care. GNOM is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.35% for XHE. GNOM is up 0.74% year-to-date (YTD) with -$602K in YTD flows. XHE performs worse with -6.1% YTD performance, and -$6M in YTD flows. Run a side-by-side ETF comparison of GNOM and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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GNOM vs XHE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | GNOM XHE | +7.67%+4.44% | -7.03%-6.33% | +0.74%-6.10% | +41.51%+4.10% | -6.56%-16.38% | -50.60%-34.81% |
| Flows | GNOM XHE | -$829K+$345K | +$1M-$4M | -$602K-$6M | -$14M-$35M | -$120M-$282M | +$1M-$404M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | GNOM XHE | +28.47%+23.06% | +27.16%+21.27% | +28.79%+21.32% | +33.22%+24.31% |
| Max drawdown | GNOM XHE | -16.08%-14.31% | -18.16%-18.20% | -46.50%-32.60% | -72.17%-49.90% |
| Max drawdown duration | GNOM XHE | 88d57d | 92d106d | 1075d1096d | 1758d1695d |
Trading data
GNOM | XHE | |
Last sale 4/27/2026 at 1:30 PM | $45.55 | $82.67 |
| Previous close 04/24/2026 | $45.97 | $82.71 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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GNOM | XHE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/27/2026 at 1:30 PM
Live
Closed
GNOM | XHE | |
|---|---|---|
| Last price | $45.55 | $82.67 |
| 1D performance | -0.92% | -0.05% |
| AuM | $51.60 M | $138.61 M |
| E/R | 0.5% | 0.35% |
Characteristics
GNOM | XHE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Global X | State Street Investment Management |
| Benchmark | Solactive Genomics Index | S&P Health Care Equipment Select Industry Index |
| N° of holdings | 45 | 61 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | April 5, 2019 | January 26, 2011 |
| ESG | No | No |
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Exposure
Countries
GNOM
USA
87.57%
Other
12.43%
XHE
USA
92.19%
Other
7.81%
Sectors
GNOM
Health Care
88.49%
Other
11.51%
XHE
Health Care
89.87%
Other
10.13%
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Diversification
GNOM
Total weight of top 15 holdings out of 15
66.21%
XHE
Total weight of top 15 holdings out of 15
26.74%
Top 15 holdings
Data as of March 31, 2026
GNOM
MODERNA INC
8.48%
ARROWHEAD PHARMACEUTICALS INC
6.21%
US74006W2070
6.13%
ILLUMINA
5.52%
GUARDANT HEALTH INC
5.18%
VERTEX PHARMACEUTICALS
4.61%
BIOMARIN PHARMACEUTICAL
4.59%
NATERA
4.21%
BIO-TECHNE CORP
3.64%
BIONTECH SE ADR
3.58%
CRISPR THERAPEUTICS
3.08%
BRISTOL-MYERS SQUIBB
3.05%
ALNYLAM PHARMACEUTICALS
2.85%
TWIST BIOSCIENCE CORP
2.54%
ASTRAZENECA
2.53%
XHE
TELEFLEX
1.86%
STAAR SURGICAL
1.84%
BUTTERFLY NETWORK INC
1.84%
US58507V1070
1.83%
GLAUKOS
1.82%
INTEGER HOLDINGS
1.79%
AXOGEN
1.79%
LIVANOVA
1.78%
MASIMO
1.76%
LEMAITRE VASCULAR
1.75%
ARTIVION INC
1.75%
HOLOGIC
1.74%
STERIS
1.74%
GLOBUS MEDICAL
1.72%
IRHYTHM TECHNOLOGIES
1.72%
Frequently asked questions about GNOM and XHE
How have the GNOM and XHE ETFs performed in 2026?
As of April 24, 2026, GNOM is up 0.74% year-to-date (YTD), while XHE has lost -6.1%. That puts GNOM better performer ahead so far this year.
Which ETF is attracting more investor money: GNOM or XHE?
Year-to-date, the GNOM ETF saw -$602K in flows, compared to -$6M for XHE.
Which ETF is more volatile: GNOM or XHE?
Over the past year, GNOM had a volatility of 27.16%, while XHE experienced 21.27%.
Which ETF is bigger: GNOM or XHE?
As of April 24, 2026, GNOM holds $51.60 M in assets under management (AUM), while XHE manages $138.61 M.
What sectors do the GNOM and XHE ETFs invest in?
GNOM leans toward sectors like Health Care. Meanwhile, XHE focuses on Health Care.
What are the top holdings of the GNOM ETF and XHE ETF?
GNOM top holdings include MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070. XHE holds in its top three: TELEFLEX, STAAR SURGICAL and BUTTERFLY NETWORK INC.
Which ETF is more diversified: GNOM or XHE?
GNOM holds 47 securities with 66.21% of its assets in the top 15. XHE has 67 securities and a top 15 weight of 26.74%.
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