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GNOMvsXHEETF Comparison

ETF 1
GNOM

Global X Genomics & Biotechnology ETF - USD

This fund is part of
BioTech & Genomics
-0.12%
Full GNOM fund page
VS
ETF 2
XHE

SPDR S&P Health Care Equipment ETF

This fund is part of
US Health Care
-0.3%
Full XHE fund page

Global X Genomics & Biotechnology ETF - USD (GNOM) belongs to the BioTech & Genomics segment. SPDR S&P Health Care Equipment ETF (XHE) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Health Care. GNOM is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.35% for XHE. GNOM is down -0.99% year-to-date (YTD) with -$2M in YTD flows. XHE performs worse with -6.79% YTD performance, and -$4M in YTD flows. Run a side-by-side ETF comparison of GNOM and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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GNOM vs XHE performance and flow charts

Performance

-6.0-4.0-2.00.02.04.0%Feb 11Feb 19Feb 26Mar 5

Cumulative Flows

Feb 11Feb 19Feb 26Mar 5

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Historic performance and flows
Data as of 03/11/2026
1M3MYTD1Y3Y5Y
Perf.
GNOM
XHE
-2.35%-4.63%
-3.29%-8.38%
-0.99%-6.79%
+29.80%-1.88%
-6.02%-7.27%
-51.80%-31.62%
Flows
GNOM
XHE
--
-$4M-$7M
-$2M-$4M
-$19M-$44M
-$115M-$295M
+$11M-$430M
Volatility and drawdown
3M1Y3Y5Y
Volatility
GNOM
XHE
+23.45%+18.94%
+30.08%+23.53%
+28.53%+21.07%
+33.47%+24.17%
Max drawdown
GNOM
XHE
-10.89%-12.38%
-22.14%-14.34%
-46.50%-32.63%
-72.17%-49.90%
Max drawdown duration
GNOM
XHE
48d62d
113d241d
1031d1053d
1714d1651d
Trading data

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GNOM
XHE
Last sale
3/11/2026 at 1:30 PM
$45.00
$82.04
Previous close
03/11/2026
$45.33
$81.73
Consolidated volume
03/11/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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GNOM
XHE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/11/2026 at 1:30 PM
Live
Closed
GNOM
XHE
Last price
$45.00
$82.04
1D performance
-0.74%
+0.38%
AuM$49.36 M$139.64 M
E/R0.5%0.35%
Characteristics
GNOM
XHE
Management strategyPassivePassive
ProviderGlobal XSPDR
BenchmarkSolactive Genomics IndexS&P Health Care Equipment Select Industry Index
N° of holdings4661
Asset classEquitiesEquities
Trailing 12m distribution yield
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Inception dateApril 5, 2019January 26, 2011
ESGNoNo
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Exposure

Countries

GNOM
USA
87.04%
Other
12.96%
XHE
USA
92.71%
Other
7.29%

Sectors

GNOM
Health Care
87.95%
Other
12.05%
XHE
Health Care
93.87%
Other
6.13%
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Diversification

GNOM

Total weight of top 15 holdings out of 15

63.95%
XHE

Total weight of top 15 holdings out of 15

30.47%

Top 15 holdings

Data as of January 31, 2026
GNOM
MODERNA INC
6.79%
ARROWHEAD PHARMACEUTICALS INC
6.14%
US74006W2070
5.75%
ILLUMINA
5.64%
GUARDANT HEALTH INC
5.47%
NATERA
4.30%
VERTEX PHARMACEUTICALS
4.08%
BIONTECH SE ADR
4.04%
BIOMARIN PHARMACEUTICAL
3.93%
AVIDITY BIOSCIENCES
3.73%
BIO-TECHNE CORP
3.69%
CRISPR THERAPEUTICS
3.05%
ALNYLAM PHARMACEUTICALS
2.58%
VERACYTE INC/D
2.50%
BRISTOL-MYERS SQUIBB
2.28%
XHE
NEOGEN
2.63%
INTEGER HOLDINGS
2.17%
PENUMBRA
2.12%
UFP TECHNOLOGY
2.11%
AXOGEN
2.09%
OMNICELL
1.98%
LANTHEUS HOLDINGS
1.98%
BAXTER INTL
1.98%
GLAUKOS
1.97%
DEXCOM
1.94%
DENTSPLY SIRONA
1.92%
BUTTERFLY NETWORK INC
1.92%
ENVISTA HOLDINGS CORP
1.91%
STRYKER
1.88%
GLOBUS MEDICAL
1.86%
Frequently asked questions about GNOM and XHE

How have the GNOM and XHE ETFs performed in 2026?

As of March 11, 2026, GNOM is down -0.99% year-to-date (YTD), while XHE has lost -6.79%. That puts GNOM better performer ahead so far this year.

Which ETF is attracting more investor money: GNOM or XHE?

Year-to-date, the GNOM ETF saw -$2M in flows, compared to -$4M for XHE.

Which ETF is more volatile: GNOM or XHE?

Over the past year, GNOM had a volatility of 30.08%, while XHE experienced 23.53%.

Which ETF is bigger: GNOM or XHE?

As of March 11, 2026, GNOM holds $49.36 M in assets under management (AUM), while XHE manages $139.64 M.

What sectors do the GNOM and XHE ETFs invest in?

GNOM leans toward sectors like Health Care. Meanwhile, XHE focuses on Health Care.

What are the top holdings of the GNOM ETF and XHE ETF?

GNOM top holdings include MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070. XHE holds in its top three: NEOGEN, INTEGER HOLDINGS and PENUMBRA.

Which ETF is more diversified: GNOM or XHE?

GNOM holds 48 securities with 63.95% of its assets in the top 15. XHE has 64 securities and a top 15 weight of 30.47%.

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