GNOMvsHELXETF Comparison
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Global X Genomics & Biotechnology ETF (GNOM) and Franklin Genomic Advancements ETF (HELX) belong to the same industry segment: BioTech & Genomics. GNOM's top 3 sector exposures are Healthcare and Industrials. In contrast, HELX's top sector exposures are Healthcare and Non-Energy Materials.Technology, Both GNOM and HELX have the same Total Expense Ratio (TER) of 0.5%. GNOM is up 21.83% year-to-date (YTD) with +$18M in YTD flows. HELX performs worse with 9.3% YTD performance, and +$6M in YTD flows. Run a side-by-side ETF comparison of GNOM and HELX below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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GNOM vs HELX performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/30/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | GNOM HELX | -2.19%-0.62% | +22.58%+18.71% | +21.83%+9.30% | +58.30%+41.04% | +14.80%+26.87% | -38.54%-25.32% |
| Flows | GNOM HELX | +$7M+$2M | +$19M+$4M | +$18M+$6M | +$13M+$10M | -$95M+$13M | -$862K+$18M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | GNOM HELX | +28.16%+24.21% | +26.78%+21.83% | +29.11%+20.99% | +33.32%+23.58% |
| Max drawdown | GNOM HELX | -8.57%-6.59% | -18.16%-17.89% | -43.10%-29.16% | -72.01%-58.50% |
| Max drawdown duration | GNOM HELX | 24d21d | 145d206d | 674d458d | 1792d1787d |
Trading data
GNOM | HELX | |
Last sale 7/31/2026 at 1:30 PM | $54.17 | $38.83 |
| Previous close 07/30/2026 | $55.39 | $39.75 |
| Consolidated volume 07/30/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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HELX
is actively managed and doesn’t replicate an indexGNOM | HELX | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/31/2026 at 1:30 PM
Live
Closed
GNOM | HELX | |
|---|---|---|
| Last price | $54.17 | $38.83 |
| 1D performance | -2.21% | -2.30% |
| AuM | $81.18 M | $29.75 M |
| E/R | 0.5% | 0.5% |
Characteristics
GNOM | HELX | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | Global X | Franklin Templeton |
| Benchmark | Solactive Genomics Index | - |
| N° of holdings | 50 | 61 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | April 5, 2019 | February 25, 2020 |
| ESG | No | No |
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Exposure
Countries
GNOM
USA
84.1%
Other
15.9%
HELX
USA
87.84%
Other
12.16%
Sectors
GNOM
Healthcare
99.75%
Other
0.25%
HELX
Healthcare
96.75%
Other
3.25%
Diversification
GNOM
Total weight of top 15 holdings out of 15
61.22%
HELX
Total weight of top 15 holdings out of 15
59.93%
Top 15 holdings
Data as of June 30, 2026
GNOM
Guardant Health, Inc.
5.78%
Twist Bioscience Corp.
5.09%
Illumina, Inc.
4.67%
Natera, Inc.
4.41%
Moderna, Inc.
4.22%
Veracyte, Inc.
4.12%
Bio-Techne Corp.
4.08%
Vertex Pharmaceuticals, Inc.
3.85%
Legend Biotech Corp.
3.82%
10X Genomics, Inc.
3.70%
Arrowhead Pharmaceuticals, Inc.
3.67%
BioMarin Pharmaceutical, Inc.
3.59%
Praxis Precision Medicines, Inc.
3.50%
CRISPR Therapeutics AG
3.36%
QIAGEN NV
3.35%
HELX
Guardant Health, Inc.
9.30%
Natera, Inc.
7.40%
Krystal Biotech, Inc.
6.51%
Ligand Pharmaceuticals, Inc.
4.56%
Adaptive Biotechnologies Corp.
4.01%
United Therapeutics Corp.
3.61%
BridgeBio Pharma, Inc.
3.39%
Eli Lilly & Co.
3.05%
Twist Bioscience Corp.
2.84%
Vertex Pharmaceuticals, Inc.
2.79%
Travere Therapeutics, Inc.
2.76%
AstraZeneca PLC
2.76%
Insmed, Inc.
2.43%
Corteva, Inc.
2.26%
SAMSUNG BIOLOGICS Co., Ltd.
2.26%
Frequently asked questions about GNOM and HELX
How have the GNOM and HELX ETFs performed in 2026?
As of July 30, 2026, GNOM is up 21.83% year-to-date (YTD), while HELX has returned 9.3%. That puts GNOM better performer ahead so far this year.
Which ETF is attracting more investor money: GNOM or HELX?
Year-to-date, the GNOM ETF saw +$18M in flows, compared to +$6M for HELX.
Which ETF is more volatile: GNOM or HELX?
Over the past year, GNOM had a volatility of 26.78%, while HELX experienced 21.83%.
Which ETF is bigger: GNOM or HELX?
As of July 30, 2026, GNOM holds $81.18 M in assets under management (AUM), while HELX manages $29.75 M.
What sectors do the GNOM and HELX ETFs invest in?
GNOM leans toward sectors like Healthcare. Meanwhile, HELX focuses on Healthcare.
What are the top holdings of the GNOM ETF and HELX ETF?
GNOM top holdings include Guardant Health, Inc., Twist Bioscience Corp. and Illumina, Inc.. HELX holds in its top three: Guardant Health, Inc., Natera, Inc. and Krystal Biotech, Inc..
Which ETF is more diversified: GNOM or HELX?
GNOM holds 50 securities with 61.22% of its assets in the top 15. HELX has 61 securities and a top 15 weight of 59.93%.
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