GNOMvsHELXETF Comparison
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Global X Genomics & Biotechnology ETF - USD (GNOM) and Franklin Genomic Advancements ETF (HELX) belong to the same industry segment: BioTech & Genomics. Both ETFs have the same top 3 sector exposures: and Health Care. Both GNOM and HELX have the same Total Expense Ratio (TER) of 0.5%. GNOM is up 0.74% year-to-date (YTD) with -$602K in YTD flows. HELX performs worse with -7.69% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of GNOM and HELX below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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GNOM vs HELX performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | GNOM HELX | +7.67%+5.41% | -7.03%-10.90% | +0.74%-7.69% | +41.51%+23.56% | -6.56%+9.47% | -50.60%-30.03% |
| Flows | GNOM HELX | -$829K- | +$1M- | -$602K+$2M | -$14M+$8M | -$120M+$9M | +$1M+$14M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | GNOM HELX | +28.47%+24.83% | +27.16%+20.80% | +28.79%+20.28% | +33.22%+23.68% |
| Max drawdown | GNOM HELX | -16.08%-16.86% | -18.16%-17.89% | -46.50%-29.16% | -72.17%-58.50% |
| Max drawdown duration | GNOM HELX | 88d88d | 92d145d | 1075d458d | 1758d1690d |
Trading data
GNOM | HELX | |
Last sale 4/24/2026 at 7:55 PM | $45.97 | $33.52 |
| Previous close 04/24/2026 | $46.16 | $33.42 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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HELX
is actively managed and doesn’t replicate an indexGNOM | HELX | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/24/2026 at 7:55 PM
Live
Closed
GNOM | HELX | |
|---|---|---|
| Last price | $45.97 | $33.52 |
| 1D performance | -0.42% | +0.32% |
| AuM | $51.60 M | $21.77 M |
| E/R | 0.5% | 0.5% |
Characteristics
GNOM | HELX | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | Global X | Franklin Templeton |
| Benchmark | Solactive Genomics Index | - |
| N° of holdings | 45 | 51 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | April 5, 2019 | February 25, 2020 |
| ESG | No | No |
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Exposure
Countries
GNOM
USA
87.57%
Other
12.43%
HELX
USA
87.6%
Other
12.4%
Sectors
GNOM
Health Care
88.49%
Other
11.51%
HELX
Health Care
89.74%
Other
10.26%
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Diversification
GNOM
Total weight of top 15 holdings out of 15
66.21%
HELX
Total weight of top 15 holdings out of 15
60.42%
Top 15 holdings
Data as of March 31, 2026
GNOM
MODERNA INC
8.48%
ARROWHEAD PHARMACEUTICALS INC
6.21%
US74006W2070
6.13%
ILLUMINA
5.52%
GUARDANT HEALTH INC
5.18%
VERTEX PHARMACEUTICALS
4.61%
BIOMARIN PHARMACEUTICAL
4.59%
NATERA
4.21%
BIO-TECHNE CORP
3.64%
BIONTECH SE ADR
3.58%
CRISPR THERAPEUTICS
3.08%
BRISTOL-MYERS SQUIBB
3.05%
ALNYLAM PHARMACEUTICALS
2.85%
TWIST BIOSCIENCE CORP
2.54%
ASTRAZENECA
2.53%
HELX
NATERA
6.89%
GUARDANT HEALTH INC
6.82%
KRYSTAL BIOTECH INC
5.46%
UTD THERAPEUT
4.40%
BRIDGEBIO PHARMA
4.36%
INSMED
4.31%
LIGAND PHARMACEUTICALS
3.80%
SAMSUNG BIOLOGICS CO LTD
3.37%
ADAPTIVE BIOTECHNOLOGIES
3.32%
ASTRAZENECA
3.24%
VERTEX PHARMACEUTICALS
3.20%
MEDPACE HOLDINGS INC
3.05%
CORTEVA INC
2.81%
ALNYLAM PHARMACEUTICALS
2.71%
REGENERON PHARMACEUTICALS
2.67%
Frequently asked questions about GNOM and HELX
How have the GNOM and HELX ETFs performed in 2026?
As of April 24, 2026, GNOM is up 0.74% year-to-date (YTD), while HELX has lost -7.69%. That puts GNOM better performer ahead so far this year.
Which ETF is attracting more investor money: GNOM or HELX?
Year-to-date, the GNOM ETF saw -$602K in flows, compared to +$2M for HELX.
Which ETF is more volatile: GNOM or HELX?
Over the past year, GNOM had a volatility of 27.16%, while HELX experienced 20.8%.
Which ETF is bigger: GNOM or HELX?
As of April 24, 2026, GNOM holds $51.60 M in assets under management (AUM), while HELX manages $21.77 M.
What sectors do the GNOM and HELX ETFs invest in?
GNOM leans toward sectors like Health Care. Meanwhile, HELX focuses on Health Care.
What are the top holdings of the GNOM ETF and HELX ETF?
GNOM top holdings include MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070. HELX holds in its top three: NATERA, GUARDANT HEALTH INC and KRYSTAL BIOTECH INC.
Which ETF is more diversified: GNOM or HELX?
GNOM holds 47 securities with 66.21% of its assets in the top 15. HELX has 60 securities and a top 15 weight of 60.42%.
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