FXHvsPBEETF Comparison
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First Trust Health Care AlphaDEX Fund ETF (FXH) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. Both ETFs have the same top 1 sector exposures: Healthcare. FXH is more expensive with a Total Expense Ratio (TER) of 0.61%, versus 0.59% for PBE. FXH is up 16.21% year-to-date (YTD) with +$65M in YTD flows. PBE performs better with 16.92% YTD performance, and +$114M in YTD flows. Run a side-by-side ETF comparison of FXH and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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FXH vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/17/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | FXH PBE | +0.53%-0.26% | +13.98%+13.33% | +16.21%+16.92% | +22.70%+36.22% | +33.57%+66.20% | +7.15%+27.45% |
| Flows | FXH PBE | +$20M+$27M | +$120M+$117M | +$65M+$114M | +$44M+$113M | -$498M+$62M | -$437M+$65M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | FXH PBE | +15.66%+19.84% | +15.54%+19.19% | +15.63%+20.47% | +16.94%+22.56% |
| Max drawdown | FXH PBE | -4.40%-5.97% | -12.07%-11.70% | -17.66%-22.21% | -28.28%-33.32% |
| Max drawdown duration | FXH PBE | 23d15d | 168d166d | 395d324d | 1742d1509d |
Trading data
FXH | PBE | |
Last sale 9/18/2026 at 1:30 PM | $130.77 | $94.91 |
| Previous close 09/17/2026 | $131.56 | $95.67 |
| Consolidated volume 09/17/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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FXH | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/18/2026 at 1:30 PM
Live
Closed
FXH | PBE | |
|---|---|---|
| Last price | $130.77 | $94.91 |
| 1D performance | -0.60% | -0.79% |
| AuM | $1.15 B | $414.12 M |
| E/R | 0.61% | 0.59% |
Characteristics
FXH | PBE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | First Trust | Invesco |
| Benchmark | StrataQuant Health Care Index | Dynamic Biotech & Genome Intellidex Index |
| N° of holdings | 72 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | May 8, 2007 | June 23, 2005 |
| ESG | No | No |
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Exposure
Countries
FXH
USA
93.07%
Other
6.93%
PBE
USA
97.13%
Other
2.87%
Sectors
FXH
Healthcare
98.24%
Other
1.76%
PBE
Healthcare
100%
Other
0%
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Diversification
FXH
Total weight of top 15 holdings out of 15
35.54%
PBE
Total weight of top 15 holdings out of 15
61.32%
Top 15 holdings
Data as of July 31, 2026
FXH
Regeneron Pharmaceuticals, Inc.
2.85%
Natera, Inc.
2.57%
Universal Health Services, Inc.
2.50%
Boston Scientific Corp.
2.49%
Pfizer Inc.
2.48%
Zimmer Biomet Holdings, Inc.
2.47%
Solventum Corp.
2.47%
Guardant Health, Inc.
2.41%
Tenet Healthcare Corp.
2.34%
Globus Medical, Inc.
2.33%
Corcept Therapeutics, Inc.
2.24%
Halozyme Therapeutics, Inc.
2.18%
Centene Corp.
2.15%
The Cigna Group
2.14%
Encompass Health Corp.
1.92%
PBE
Amgen, Inc.
5.16%
Vertex Pharmaceuticals, Inc.
4.96%
Royalty Pharma Plc
4.91%
Regeneron Pharmaceuticals, Inc.
4.90%
Biogen, Inc.
4.85%
Gilead Sciences, Inc.
4.44%
Alnylam Pharmaceuticals, Inc.
4.34%
United Therapeutics Corp.
4.06%
CareDx, Inc.
4.01%
Bio-Techne Corp.
3.66%
Illumina, Inc.
3.27%
Vericel Corp.
3.25%
Protagonist Therapeutics, Inc.
3.24%
Incyte Corp.
3.19%
Veracyte, Inc.
3.07%
Frequently asked questions about FXH and PBE
How have the FXH and PBE ETFs performed in 2026?
As of September 17, 2026, FXH is up 16.21% year-to-date (YTD), while PBE has returned 16.92%. That puts PBE better performer ahead so far this year.
Which ETF is attracting more investor money: FXH or PBE?
Year-to-date, the FXH ETF saw +$65M in flows, compared to +$114M for PBE.
Which ETF is more volatile: FXH or PBE?
Over the past year, FXH had a volatility of 15.54%, while PBE experienced 19.19%.
Which ETF is bigger: FXH or PBE?
As of September 17, 2026, FXH holds $1.15 B in assets under management (AUM), while PBE manages $414.12 M.
What sectors do the FXH and PBE ETFs invest in?
FXH leans toward sectors like Healthcare. Meanwhile, PBE focuses on Healthcare.
What are the top holdings of the FXH ETF and PBE ETF?
FXH top holdings include Regeneron Pharmaceuticals, Inc., Natera, Inc. and Universal Health Services, Inc.. PBE holds in its top three: Amgen, Inc., Vertex Pharmaceuticals, Inc. and Royalty Pharma Plc.
Which ETF is more diversified: FXH or PBE?
FXH holds 72 securities with 35.54% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 61.32%.
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