FXHvsPBEETF Comparison
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First Trust Health Care AlphaDEX Fund ETF (FXH) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. FXH is more expensive with a Total Expense Ratio (TER) of 0.61%, versus 0.58% for PBE. FXH is down -1.02% year-to-date (YTD) with -$56M in YTD flows. PBE performs worse with -4.24% YTD performance, and -$4M in YTD flows. Run a side-by-side ETF comparison of FXH and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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FXH vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | FXH PBE | +6.72%+2.23% | -2.22%-4.67% | -1.02%-4.24% | +14.25%+28.66% | +4.49%+25.55% | -1.02%+4.21% |
| Flows | FXH PBE | +$354K+$18K | -$62M-$8M | -$56M-$4M | -$118M-$32M | -$713M-$60M | -$500M-$44M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | FXH PBE | +17.09%+19.62% | +16.22%+19.88% | +15.23%+20.13% | +16.68%+22.54% |
| Max drawdown | FXH PBE | -9.86%-9.36% | -12.07%-11.70% | -17.89%-22.21% | -29.40%-34.74% |
| Max drawdown duration | FXH PBE | 58d80d | 111d112d | 331d324d | 1695d1540d |
Trading data
FXH | PBE | |
Last sale 4/30/2026 at 1:30 PM | $112.93 | $79.58 |
| Previous close 04/29/2026 | $111.91 | $78.51 |
| Consolidated volume 04/29/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of April 29, 2026
1-year trailing difference
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FXH | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/30/2026 at 1:30 PM
Live
Closed
FXH | PBE | |
|---|---|---|
| Last price | $112.93 | $79.58 |
| 1D performance | +0.91% | +1.36% |
| AuM | $870.97 M | $244.25 M |
| E/R | 0.61% | 0.58% |
Characteristics
FXH | PBE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | First Trust | Invesco |
| Benchmark | StrataQuant Health Care Index | Dynamic Biotech & Genome Intellidex Index |
| N° of holdings | 71 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | May 8, 2007 | June 23, 2005 |
| ESG | No | No |
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Exposure
Countries
FXH
USA
95.47%
Other
4.53%
PBE
USA
92.18%
Other
7.82%
Sectors
FXH
Health Care
93.76%
Other
6.24%
PBE
Health Care
97.59%
Other
2.41%
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Diversification
FXH
Total weight of top 15 holdings out of 15
35.37%
PBE
Total weight of top 15 holdings out of 15
63.66%
Top 15 holdings
Data as of March 31, 2026
FXH
ACADIA HEALTHCARE COMPANY
3.83%
APELLIS PHARMACEUTICALS
2.95%
PFIZER
2.63%
BIOGEN INC
2.40%
CARDINAL HEALTH
2.37%
HCA HEALTHCARE
2.33%
INCYTE
2.19%
IONIS PHARMACEUTICALS INC
2.18%
INSMED
2.17%
UTD THERAPEUT
2.15%
MERCK & CO INC
2.11%
NATERA
2.04%
LILLY
2.04%
MEDPACE HOLDINGS INC
2.00%
AMGEN-T
1.98%
PBE
UTD THERAPEUT
6.05%
ILLUMINA
5.24%
REGENERON PHARMACEUTICALS
5.23%
ALNYLAM PHARMACEUTICALS
5.22%
BIOGEN INC
5.16%
AMGEN-T
4.99%
GILEAD SCIENCES
4.98%
INCYTE
4.89%
BIOCRYST PHARMACEUTICALS
3.66%
PROTAGONIST THERAPEUTICS INC
3.38%
TG THERAPEUTICS
3.11%
ROYALTY PHARMA
3.05%
NEUROCRINE BIOSCIENCES
2.93%
CATALYST PHARMACEUTICALS INC
2.89%
PTC THERAPEUTI/D
2.86%
Frequently asked questions about FXH and PBE
How have the FXH and PBE ETFs performed in 2026?
As of April 28, 2026, FXH is down -1.02% year-to-date (YTD), while PBE has lost -4.24%. That puts FXH better performer ahead so far this year.
Which ETF is attracting more investor money: FXH or PBE?
Year-to-date, the FXH ETF saw -$56M in flows, compared to -$4M for PBE.
Which ETF is more volatile: FXH or PBE?
Over the past year, FXH had a volatility of 16.22%, while PBE experienced 19.88%.
Which ETF is bigger: FXH or PBE?
As of April 28, 2026, FXH holds $870.97 M in assets under management (AUM), while PBE manages $244.25 M.
What sectors do the FXH and PBE ETFs invest in?
FXH leans toward sectors like Health Care. Meanwhile, PBE focuses on Health Care.
What are the top holdings of the FXH ETF and PBE ETF?
FXH top holdings include ACADIA HEALTHCARE COMPANY, APELLIS PHARMACEUTICALS and PFIZER. PBE holds in its top three: UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS.
Which ETF is more diversified: FXH or PBE?
FXH holds 75 securities with 35.37% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 63.66%.
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