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FTXHvsXLVIETF Comparison
The Health Care Select Sector SPDR Premium Income Fund
First Trust Nasdaq Pharmaceuticals ETF (FTXH) belongs to the US Health Care segment. The Health Care Select Sector SPDR Premium Income Fund (XLVI) is part of the Options Strategies segment. Both ETFs have the same top 3 sector exposures: and Health Care. FTXH is more expensive with a Total Expense Ratio (TER) of 0.6%, versus 0.35% for XLVI. FTXH is up 5.06% year-to-date (YTD) with +$7M in YTD flows. XLVI performs worse with 0.43% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of FTXH and XLVI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
FTXH vs XLVI performance and flow charts
Performance
Cumulative Flows
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | FTXH XLVI | -0.60%-0.34% | +7.47%+2.91% | +5.06%+0.43% | +22.29%n/a | +43.33%n/a | +43.47%n/a |
| Flows | FTXH XLVI | +$5M+$788K | +$9M+$3M | +$7M+$2M | +$10M- | -$13M- | +$4M- |
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | FTXH XLVI | +15.29%+10.28% | +20.64%n/a | +15.87%n/a | +15.67%n/a |
| Max drawdown | FTXH XLVI | -4.33%-3.26% | -17.49%n/a | -19.32%n/a | -19.32%n/a |
| Max drawdown duration | FTXH XLVI | 9d9d | 203dn/a | 393dn/a | 393dn/a |
FTXH | XLVI | |
Last sale 3/11/2026 at 1:30 PM | $34.46 | $25.92 |
| Previous close 03/10/2026 | $34.57 | $25.98 |
| Consolidated volume 03/10/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Create an account to view replication metrics
FTXH | XLVI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
FTXH | XLVI | |
|---|---|---|
| Last price | $34.46 | $25.92 |
| 1D performance | -0.33% | -0.23% |
| AuM | $29.41 M | $13.26 M |
| E/R | 0.6% | 0.35% |
FTXH | XLVI | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | First Trust | SPDR |
| Benchmark | NASDAQ US Smart Pharmaceuticals Index | - |
| N° of holdings | 49 | 57 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | September 20, 2016 | July 30, 2025 |
| ESG | No | No |
Countries
Sectors
Diversification
Total weight of top 15 holdings out of 15
Total weight of top 15 holdings out of 15
Top 15 holdings
How have the FTXH and XLVI ETFs performed in 2026?
As of March 10, 2026, FTXH is up 5.06% year-to-date (YTD), while XLVI has returned 0.43%. That puts FTXH better performer ahead so far this year.
Which ETF is attracting more investor money: FTXH or XLVI?
Year-to-date, the FTXH ETF saw +$7M in flows, compared to +$2M for XLVI.
Which ETF is bigger: FTXH or XLVI?
As of March 10, 2026, FTXH holds $29.41 M in assets under management (AUM), while XLVI manages $13.26 M.
What sectors do the FTXH and XLVI ETFs invest in?
FTXH leans toward sectors like Health Care. Meanwhile, XLVI focuses on Health Care.
What are the top holdings of the FTXH ETF and XLVI ETF?
FTXH top holdings include MERCK & CO INC, JOHNSON&JOHNSON and BRISTOL-MYERS SQUIBB. XLVI holds in its top three: LILLY, JOHNSON&JOHNSON and ABBVIE.
Which ETF is more diversified: FTXH or XLVI?
FTXH holds 50 securities with 71.63% of its assets in the top 15. XLVI has 60 securities and a top 15 weight of 69.69%.
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