FMEDvsTDNAETF Comparison
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Fidelity Disruptive Medicine ETF (FMED) belongs to the Multiple Trends segment. T. Rowe Price Biotech ETF (TDNA) is part of the Uncategorized Equities segment. Both ETFs have the same top 1 sector exposures: Healthcare. FMED is less expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.55% for TDNA. Run a side-by-side ETF comparison of FMED and TDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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FMED vs TDNA performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/30/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | FMED TDNA | +0.80%+0.68% | +13.11%n/a | +19.85%n/a | +23.23%n/a | +63.30%n/a | n/an/a |
| Flows | FMED TDNA | -+$568K | -- | -$17M- | -$14M- | -$12M- | -- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | FMED TDNA | +28.29%n/a | +22.86%n/a | +19.81%n/a | n/an/a |
| Max drawdown | FMED TDNA | -7.63%n/a | -17.78%n/a | -19.20%n/a | n/an/a |
| Max drawdown duration | FMED TDNA | 69dn/a | 212dn/a | 267dn/a | n/an/a |
Trading data
FMED | TDNA | |
Last sale 11/2/2026 at 3:57 PM | $24.50 | |
| Previous close 10/29/2026 | $24.72 | |
| Consolidated volume 10/29/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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Main metrics
Last update 11/2/2026 at 3:57 PM
Live
Closed
FMED | TDNA | |
|---|---|---|
| Last price | – | $24.50 |
| 1D performance | – | -0.89% |
| AuM | $52.73 M | $10.69 M |
| E/R | 0.5% | 0.55% |
Characteristics
FMED | TDNA | |
|---|---|---|
| Management strategy | Active | Active |
| Provider | Fidelity | T. Rowe Price |
| Benchmark | - | - |
| N° of holdings | 71 | 86 |
| Asset class | - | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 12, 2023 | September 16, 2026 |
| ESG | No | No |
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Exposure
Countries
FMED
USA
84.97%
Other
15.03%
TDNA
USA
88.46%
Other
11.54%
Sectors
FMED
Healthcare
99.49%
Other
0.51%
TDNA
Healthcare
98.5%
Other
1.5%
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Diversification
FMED
Total weight of top 15 holdings out of 15
47.18%
TDNA
Total weight of top 15 holdings out of 15
37.16%
Top 15 holdings
Data as of September 30, 2026
FMED
10X Genomics, Inc.
5.82%
Natera, Inc.
4.47%
Thermo Fisher Scientific, Inc.
4.19%
Danaher Corp.
3.92%
Illumina, Inc.
3.56%
argenx SE
2.96%
Lifestance Health Group, Inc.
2.87%
Revolution Medicines, Inc.
2.86%
Sartorius Stedim Biotech SA
2.72%
Moderna, Inc.
2.62%
Alnylam Pharmaceuticals, Inc.
2.48%
HeartFlow, Inc.
2.39%
Intuitive Surgical, Inc.
2.20%
Cogent Biosciences, Inc.
2.13%
Caris Life Sciences, Inc.
1.99%
TDNA
argenx SE
5.41%
Kymera Therapeutics, Inc.
4.04%
Kodiak Sciences, Inc.
2.68%
Insmed, Inc.
2.59%
Natera, Inc.
2.41%
Revolution Medicines, Inc.
2.37%
Vertex Pharmaceuticals, Inc.
2.25%
United Therapeutics Corp.
2.20%
Alnylam Pharmaceuticals, Inc.
1.98%
Dianthus Therapeutics, Inc.
1.91%
Praxis Precision Medicines, Inc.
1.91%
Moderna, Inc.
1.90%
Vaxcyte, Inc.
1.86%
Cytokinetics, Inc.
1.83%
Rhythm Pharmaceuticals, Inc.
1.81%
Frequently asked questions about FMED and TDNA
Which ETF is bigger: FMED or TDNA?
As of October 30, 2026, FMED holds $52.73 M in assets under management (AUM), while TDNA manages $10.69 M.
What sectors do the FMED and TDNA ETFs invest in?
FMED leans toward sectors like Healthcare. Meanwhile, TDNA focuses on Healthcare.
What are the top holdings of the FMED ETF and TDNA ETF?
FMED top holdings include 10X Genomics, Inc., Natera, Inc. and Thermo Fisher Scientific, Inc.. TDNA holds in its top three: argenx SE, Kymera Therapeutics, Inc. and Kodiak Sciences, Inc..
Which ETF is more diversified: FMED or TDNA?
FMED holds 71 securities with 47.18% of its assets in the top 15. TDNA has 86 securities and a top 15 weight of 37.16%.
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