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FMEDvsIBBQETF Comparison

ETF 1

FMED

Fidelity Disruptive Medicine ETF

This fund is part of

Multiple Trends

-6.5%

Full FMED fund page

VS

ETF 2

IBBQ

Invesco Nasdaq Biotechnology ETF

This fund is part of

US Health Care

-3.27%

Full IBBQ fund page

Fidelity Disruptive Medicine ETF (FMED) belongs to the Multiple Trends segment. Invesco Nasdaq Biotechnology ETF (IBBQ) is part of the US Health Care segment. FMED's top 1 sector exposures are Healthcare. In contrast, IBBQ's top sector exposures are Healthcare and Non-Energy Materials. FMED is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.19% for IBBQ. FMED is up 14.76% year-to-date (YTD) with -$20M in YTD flows. IBBQ performs better with 24.65% YTD performance, and +$46M in YTD flows. Run a side-by-side ETF comparison of FMED and IBBQ below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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FMED vs IBBQ performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 11/05/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	FMED IBBQ	-4.35%+1.02%	+7.81%+7.06%	+14.76%+24.65%	+19.85%+33.86%	+48.91%+87.32%	n/a+47.70%
Flows	FMED IBBQ	-$3M+$12M	-$3M+$43M	-$20M+$46M	-$18M+$63M	-$15M+$82M	-+$60M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	FMED IBBQ	+31.58%+27.64%	+24.11%+23.18%	+20.23%+21.41%	n/a+22.30%
Max drawdown	FMED IBBQ	-7.63%-8.58%	-17.78%-8.58%	-19.20%-23.78%	n/a-31.91%
Max drawdown duration	FMED IBBQ	69d76d	212d76d	267d375d	n/a980d

Trading data

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	FMED	IBBQ
Last sale 11/6/2026 at 2:30 PM		$35.83
Previous close 11/04/2026		$35.10
Consolidated volume 11/04/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of October 30, 2026

1-year trailing difference

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FMED

is actively managed and doesn’t replicate an index

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	FMED	IBBQ
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 11/6/2026 at 2:30 PM

Live

Closed

	FMED	IBBQ
Last price	–	$35.83
1D performance	–	+2.08%
AuM	$47.38 M	$125.15 M
E/R	0.5%	0.19%

Characteristics

	FMED	IBBQ
Management strategy	Active	Passive
Provider	Fidelity	Invesco
Benchmark	-	NASDAQ Biotechnology Index
N° of holdings	71	245
Asset class	-	Equities
Trailing 12m distribution yield	Join	Join
Inception date	June 12, 2023	June 9, 2021
ESG	No	No

More FMED data on Trackinsight

More IBBQ data on Trackinsight

Exposure

Countries

FMED

USA

84.97%

Other

15.03%

IBBQ

USA

88.6%

Other

11.4%

Sectors

FMED

Healthcare

99.49%

Other

0.51%

IBBQ

Healthcare

99.99%

Other

0.01%

Diversification

FMED

Total weight of top 15 holdings out of 15

47.18%

IBBQ

Total weight of top 15 holdings out of 15

54.02%

Top 15 holdings

Data as of September 30, 2026

FMED

10X Genomics, Inc.

5.82%

Natera, Inc.

4.47%

Thermo Fisher Scientific, Inc.

4.19%

Danaher Corp.

3.92%

Illumina, Inc.

3.56%

argenx SE

2.96%

Lifestance Health Group, Inc.

2.87%

Revolution Medicines, Inc.

2.86%

Sartorius Stedim Biotech SA

2.72%

Moderna, Inc.

2.62%

Alnylam Pharmaceuticals, Inc.

2.48%

HeartFlow, Inc.

2.39%

Intuitive Surgical, Inc.

2.20%

Cogent Biosciences, Inc.

2.13%

Caris Life Sciences, Inc.

1.99%

IBBQ

Gilead Sciences, Inc.

8.32%

Amgen, Inc.

7.78%

Vertex Pharmaceuticals, Inc.

7.75%

Moderna, Inc.

5.16%

Regeneron Pharmaceuticals, Inc.

4.98%

Revolution Medicines, Inc.

2.83%

Illumina, Inc.

2.69%

Alnylam Pharmaceuticals, Inc.

2.24%

Biogen, Inc.

2.21%

Roivant Sciences Ltd.

1.75%

argenx SE

1.74%

Royalty Pharma Plc

1.70%

Insmed, Inc.

1.68%

Incyte Corp.

1.66%

Guardant Health, Inc.

1.56%

Frequently asked questions about FMED and IBBQ

How have the FMED and IBBQ ETFs performed in 2026?

As of November 5, 2026, FMED is up 14.76% year-to-date (YTD), while IBBQ has returned 24.65%. That puts IBBQ better performer ahead so far this year.

Which ETF is attracting more investor money: FMED or IBBQ?

Year-to-date, the FMED ETF saw -$20M in flows, compared to +$46M for IBBQ.

Which ETF is more volatile: FMED or IBBQ?

Over the past year, FMED had a volatility of 24.11%, while IBBQ experienced 23.18%.

Which ETF is bigger: FMED or IBBQ?

As of November 5, 2026, FMED holds $47.38 M in assets under management (AUM), while IBBQ manages $125.15 M.

What sectors do the FMED and IBBQ ETFs invest in?

FMED leans toward sectors like Healthcare. Meanwhile, IBBQ focuses on Healthcare.

What are the top holdings of the FMED ETF and IBBQ ETF?

FMED top holdings include 10X Genomics, Inc., Natera, Inc. and Thermo Fisher Scientific, Inc.. IBBQ holds in its top three: Gilead Sciences, Inc., Amgen, Inc. and Vertex Pharmaceuticals, Inc..

FMEDvsIBBQETF Comparison

Fidelity Disruptive Medicine ETF

Invesco Nasdaq Biotechnology ETF

FMED vs IBBQ performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the FMED and IBBQ ETFs performed in 2026?

As of November 5, 2026, FMED is up 14.76% year-to-date (YTD), while IBBQ has returned 24.65%. That puts IBBQ better performer ahead so far this year.

Which ETF is attracting more investor money: FMED or IBBQ?

Year-to-date, the FMED ETF saw -$20M in flows, compared to +$46M for IBBQ.

Which ETF is more volatile: FMED or IBBQ?

Over the past year, FMED had a volatility of 24.11%, while IBBQ experienced 23.18%.

Which ETF is bigger: FMED or IBBQ?

As of November 5, 2026, FMED holds $47.38 M in assets under management (AUM), while IBBQ manages $125.15 M.

What sectors do the FMED and IBBQ ETFs invest in?

FMED leans toward sectors like Healthcare. Meanwhile, IBBQ focuses on Healthcare.

What are the top holdings of the FMED ETF and IBBQ ETF?

FMED top holdings include 10X Genomics, Inc., Natera, Inc. and Thermo Fisher Scientific, Inc.. IBBQ holds in its top three: Gilead Sciences, Inc., Amgen, Inc. and Vertex Pharmaceuticals, Inc..

Which ETF is more diversified: FMED or IBBQ?

FMED holds 71 securities with 47.18% of its assets in the top 15. IBBQ has 245 securities and a top 15 weight of 54.02%.

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