FMEDvsHELXETF Comparison
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Fidelity Disruptive Medicine ETF (FMED) belongs to the Multiple Trends segment. Franklin Genomic Advancements ETF (HELX) is part of the BioTech & Genomics segment. FMED's top 1 sector exposures are Healthcare. In contrast, HELX's top sector exposures are Healthcare, Non-Energy Materials and Technology. Both FMED and HELX have the same Total Expense Ratio (TER) of 0.5%. FMED is up 17.43% year-to-date (YTD) with -$17M in YTD flows. HELX performs better with 18.76% YTD performance, and +$6M in YTD flows. Run a side-by-side ETF comparison of FMED and HELX below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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FMED vs HELX performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/21/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | FMED HELX | -2.40%-0.25% | +21.48%+18.66% | +17.43%+18.76% | +29.04%+38.96% | +43.82%+51.68% | n/a-23.60% |
| Flows | FMED HELX | -- | -+$4M | -$17M+$6M | -$14M+$8M | -$3M+$15M | --$2M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | FMED HELX | +24.66%+24.95% | +21.06%+22.98% | +19.25%+21.46% | n/a+23.56% |
| Max drawdown | FMED HELX | -7.15%-6.59% | -17.78%-17.89% | -19.20%-29.16% | n/a-58.16% |
| Max drawdown duration | FMED HELX | 29d28d | 212d206d | 267d458d | n/a1824d |
Trading data
FMED | HELX | |
Last sale 9/21/2026 at 1:30 PM | $43.10 | |
| Previous close 09/21/2026 | $42.83 | |
| Consolidated volume 09/21/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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Main metrics
Last update 9/21/2026 at 1:30 PM
Live
Closed
FMED | HELX | |
|---|---|---|
| Last price | – | $43.10 |
| 1D performance | – | +0.63% |
| AuM | $51.66 M | $32.32 M |
| E/R | 0.5% | 0.5% |
Characteristics
FMED | HELX | |
|---|---|---|
| Management strategy | Active | Active |
| Provider | Fidelity | Franklin Templeton |
| Benchmark | - | - |
| N° of holdings | 74 | 66 |
| Asset class | - | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 12, 2023 | February 25, 2020 |
| ESG | No | No |
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Exposure
Countries
FMED
USA
83.4%
Other
16.6%
HELX
USA
86.99%
Other
13.01%
Sectors
FMED
Healthcare
100%
Other
0%
HELX
Healthcare
96.35%
Other
3.65%
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Diversification
FMED
Total weight of top 15 holdings out of 15
43.09%
HELX
Total weight of top 15 holdings out of 15
60.19%
Top 15 holdings
Data as of July 31, 2026
FMED
10X Genomics, Inc.
4.48%
Thermo Fisher Scientific, Inc.
3.98%
Danaher Corp.
3.86%
Lifestance Health Group, Inc.
3.15%
Alnylam Pharmaceuticals, Inc.
3.10%
argenx SE
2.99%
Cogent Biosciences, Inc.
2.98%
Revolution Medicines, Inc.
2.85%
Illumina, Inc.
2.62%
Intuitive Surgical, Inc.
2.34%
Kymera Therapeutics, Inc.
2.29%
UnitedHealth Group, Inc.
2.24%
Ascendis Pharma A/S
2.12%
Kiniksa Pharmaceuticals International Plc
2.06%
UCB SA
2.03%
HELX
Guardant Health, Inc.
9.10%
Natera, Inc.
7.31%
Krystal Biotech, Inc.
6.17%
Ligand Pharmaceuticals, Inc.
4.48%
Adaptive Biotechnologies Corp.
4.33%
BridgeBio Pharma, Inc.
4.08%
United Therapeutics Corp.
3.52%
Eli Lilly & Co.
3.04%
Vertex Pharmaceuticals, Inc.
2.73%
SAMSUNG BIOLOGICS Co., Ltd.
2.72%
Travere Therapeutics, Inc.
2.67%
Corteva, Inc.
2.65%
AstraZeneca PLC
2.49%
Twist Bioscience Corp.
2.47%
Medpace Holdings, Inc.
2.44%
Frequently asked questions about FMED and HELX
How have the FMED and HELX ETFs performed in 2026?
As of September 21, 2026, FMED is up 17.43% year-to-date (YTD), while HELX has returned 18.76%. That puts HELX better performer ahead so far this year.
Which ETF is attracting more investor money: FMED or HELX?
Year-to-date, the FMED ETF saw -$17M in flows, compared to +$6M for HELX.
Which ETF is more volatile: FMED or HELX?
Over the past year, FMED had a volatility of 21.06%, while HELX experienced 22.98%.
Which ETF is bigger: FMED or HELX?
As of September 21, 2026, FMED holds $51.66 M in assets under management (AUM), while HELX manages $32.32 M.
What sectors do the FMED and HELX ETFs invest in?
FMED leans toward sectors like Healthcare. Meanwhile, HELX focuses on Healthcare.
What are the top holdings of the FMED ETF and HELX ETF?
FMED top holdings include 10X Genomics, Inc., Thermo Fisher Scientific, Inc. and Danaher Corp.. HELX holds in its top three: Guardant Health, Inc., Natera, Inc. and Krystal Biotech, Inc..
Which ETF is more diversified: FMED or HELX?
FMED holds 74 securities with 43.09% of its assets in the top 15. HELX has 66 securities and a top 15 weight of 60.19%.
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