FMEDvsHELXETF Comparison
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Fidelity Disruptive Medicine ETF (FMED) belongs to the Multiple Trends segment. Franklin Genomic Advancements ETF (HELX) is part of the BioTech & Genomics segment. FMED's top 1 sector exposures are Healthcare. In contrast, HELX's top sector exposures are Healthcare, Non-Energy Materials and Technology. Both FMED and HELX have the same Total Expense Ratio (TER) of 0.5%. FMED is up 14.76% year-to-date (YTD) with -$20M in YTD flows. HELX performs better with 15.93% YTD performance, and +$8M in YTD flows. Run a side-by-side ETF comparison of FMED and HELX below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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FMED vs HELX performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 11/05/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | FMED HELX | -4.35%-6.85% | +7.81%+5.04% | +14.76%+15.93% | +19.85%+20.51% | +48.91%+57.61% | n/a-16.60% |
| Flows | FMED HELX | -$3M+$2M | -$3M+$2M | -$20M+$8M | -$18M+$8M | -$15M+$17M | -+$8M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | FMED HELX | +31.58%+30.93% | +24.11%+25.32% | +20.23%+22.30% | n/a+23.85% |
| Max drawdown | FMED HELX | -7.63%-8.93% | -17.78%-17.89% | -19.20%-29.16% | n/a-52.92% |
| Max drawdown duration | FMED HELX | 69d22d | 212d206d | 267d458d | n/a1823d |
Trading data
FMED | HELX | |
Last sale 11/6/2026 at 2:30 PM | $42.19 | |
| Previous close 11/04/2026 | $42.04 | |
| Consolidated volume 11/04/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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Main metrics
Last update 11/6/2026 at 2:30 PM
Live
Closed
FMED | HELX | |
|---|---|---|
| Last price | – | $42.19 |
| 1D performance | – | +0.37% |
| AuM | $47.38 M | $33.65 M |
| E/R | 0.5% | 0.5% |
Characteristics
FMED | HELX | |
|---|---|---|
| Management strategy | Active | Active |
| Provider | Fidelity | Franklin Templeton |
| Benchmark | - | - |
| N° of holdings | 71 | 66 |
| Asset class | - | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 12, 2023 | February 25, 2020 |
| ESG | No | No |
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Exposure
Countries
FMED
USA
84.97%
Other
15.03%
HELX
USA
90.13%
Other
9.87%
Sectors
FMED
Healthcare
99.49%
Other
0.51%
HELX
Healthcare
97.01%
Other
2.99%
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Diversification
FMED
Total weight of top 15 holdings out of 15
47.18%
HELX
Total weight of top 15 holdings out of 15
61.42%
Top 15 holdings
Data as of September 30, 2026
FMED
10X Genomics, Inc.
5.82%
Natera, Inc.
4.47%
Thermo Fisher Scientific, Inc.
4.19%
Danaher Corp.
3.92%
Illumina, Inc.
3.56%
argenx SE
2.96%
Lifestance Health Group, Inc.
2.87%
Revolution Medicines, Inc.
2.86%
Sartorius Stedim Biotech SA
2.72%
Moderna, Inc.
2.62%
Alnylam Pharmaceuticals, Inc.
2.48%
HeartFlow, Inc.
2.39%
Intuitive Surgical, Inc.
2.20%
Cogent Biosciences, Inc.
2.13%
Caris Life Sciences, Inc.
1.99%
HELX
Natera, Inc.
10.25%
Guardant Health, Inc.
9.72%
Krystal Biotech, Inc.
5.32%
Twist Bioscience Corp.
5.01%
Adaptive Biotechnologies Corp.
4.95%
Ligand Pharmaceuticals, Inc.
4.33%
BridgeBio Pharma, Inc.
2.79%
Travere Therapeutics, Inc.
2.72%
Medpace Holdings, Inc.
2.64%
Vertex Pharmaceuticals, Inc.
2.62%
Corteva, Inc.
2.33%
Eli Lilly & Co.
2.25%
Tempus AI, Inc.
2.25%
United Therapeutics Corp.
2.20%
Repligen Corp.
2.04%
Frequently asked questions about FMED and HELX
How have the FMED and HELX ETFs performed in 2026?
As of November 5, 2026, FMED is up 14.76% year-to-date (YTD), while HELX has returned 15.93%. That puts HELX better performer ahead so far this year.
Which ETF is attracting more investor money: FMED or HELX?
Year-to-date, the FMED ETF saw -$20M in flows, compared to +$8M for HELX.
Which ETF is more volatile: FMED or HELX?
Over the past year, FMED had a volatility of 24.11%, while HELX experienced 25.32%.
Which ETF is bigger: FMED or HELX?
As of November 5, 2026, FMED holds $47.38 M in assets under management (AUM), while HELX manages $33.65 M.
What sectors do the FMED and HELX ETFs invest in?
FMED leans toward sectors like Healthcare. Meanwhile, HELX focuses on Healthcare.
What are the top holdings of the FMED ETF and HELX ETF?
FMED top holdings include 10X Genomics, Inc., Natera, Inc. and Thermo Fisher Scientific, Inc.. HELX holds in its top three: Natera, Inc., Guardant Health, Inc. and Krystal Biotech, Inc..
Which ETF is more diversified: FMED or HELX?
FMED holds 71 securities with 47.18% of its assets in the top 15. HELX has 66 securities and a top 15 weight of 61.42%.
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