FBTvsPBEETF Comparison
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First Trust NYSE Arca Biotechnology Index Fund ETF (FBT) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Healthcare. FBT is less expensive with a Total Expense Ratio (TER) of 0.54%, versus 0.58% for PBE. FBT is up 22.01% year-to-date (YTD) with +$1.00B in YTD flows. PBE performs worse with 12.84% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of FBT and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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FBT vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | FBT PBE | +1.40%+1.97% | +23.56%+16.35% | +22.01%+12.84% | +51.49%+41.84% | +62.29%+47.30% | +49.36%+23.78% |
| Flows | FBT PBE | -$122M+$5M | -$70M+$6M | +$1.00B+$2M | +$1.06B-$17M | +$609M-$51M | +$269M-$45M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | FBT PBE | +21.83%+19.07% | +21.24%+18.93% | +20.64%+20.29% | +22.13%+22.48% |
| Max drawdown | FBT PBE | -4.37%-4.30% | -14.27%-11.70% | -19.92%-22.21% | -29.91%-34.74% |
| Max drawdown duration | FBT PBE | 21d21d | 126d166d | 237d324d | 1159d1540d |
Trading data
FBT | PBE | |
Last sale 7/29/2026 at 6:24 PM | $250.99 | $91.30 |
| Previous close 07/28/2026 | $251.31 | $91.74 |
| Consolidated volume 07/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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FBT | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/29/2026 at 6:24 PM
Live
Closed
FBT | PBE | |
|---|---|---|
| Last price | $250.99 | $91.30 |
| 1D performance | -0.13% | -0.48% |
| AuM | $2.78 B | $288.75 M |
| E/R | 0.54% | 0.58% |
Characteristics
FBT | PBE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | First Trust | Invesco |
| Benchmark | NYSE Arca Biotechnology Index | Dynamic Biotech & Genome Intellidex Index |
| N° of holdings | 30 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | June 23, 2005 |
| ESG | No | No |
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Exposure
Countries
FBT
USA
84.94%
Other
15.06%
PBE
USA
97.25%
Other
2.75%
Sectors
FBT
Healthcare
99.93%
Other
0.07%
PBE
Healthcare
100%
Other
-0%
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Diversification
FBT
Total weight of top 15 holdings out of 15
59.85%
PBE
Total weight of top 15 holdings out of 15
60.29%
Top 15 holdings
Data as of June 30, 2026
FBT
Corcept Therapeutics, Inc.
5.66%
NeoGenomics, Inc.
5.22%
Veracyte, Inc.
5.16%
Bruker Corp.
4.33%
Alkermes Plc
4.16%
Illumina, Inc.
4.08%
Krystal Biotech, Inc.
3.85%
Natera, Inc.
3.84%
Axsome Therapeutics, Inc.
3.62%
Neurocrine Biosciences, Inc.
3.49%
Bio-Techne Corp.
3.43%
Arrowhead Pharmaceuticals, Inc.
3.31%
Exelixis, Inc.
3.27%
Biogen, Inc.
3.25%
Incyte Corp.
3.18%
PBE
Vertex Pharmaceuticals, Inc.
5.12%
Biogen, Inc.
5.08%
Amgen, Inc.
4.84%
Royalty Pharma Plc
4.74%
Regeneron Pharmaceuticals, Inc.
4.53%
Alnylam Pharmaceuticals, Inc.
4.48%
Gilead Sciences, Inc.
4.34%
United Therapeutics Corp.
4.26%
Bio-Techne Corp.
3.67%
Veracyte, Inc.
3.39%
CareDx, Inc.
3.31%
Vericel Corp.
3.27%
Repligen Corp.
3.16%
PTC Therapeutics, Inc.
3.09%
Protagonist Therapeutics, Inc.
3.02%
Frequently asked questions about FBT and PBE
How have the FBT and PBE ETFs performed in 2026?
As of July 28, 2026, FBT is up 22.01% year-to-date (YTD), while PBE has returned 12.84%. That puts FBT better performer ahead so far this year.
Which ETF is attracting more investor money: FBT or PBE?
Year-to-date, the FBT ETF saw +$1.00B in flows, compared to +$2M for PBE.
Which ETF is more volatile: FBT or PBE?
Over the past year, FBT had a volatility of 21.24%, while PBE experienced 18.93%.
Which ETF is bigger: FBT or PBE?
As of July 28, 2026, FBT holds $2.78 B in assets under management (AUM), while PBE manages $288.75 M.
What sectors do the FBT and PBE ETFs invest in?
FBT leans toward sectors like Healthcare. Meanwhile, PBE focuses on Healthcare.
What are the top holdings of the FBT ETF and PBE ETF?
FBT top holdings include Corcept Therapeutics, Inc., NeoGenomics, Inc. and Veracyte, Inc.. PBE holds in its top three: Vertex Pharmaceuticals, Inc., Biogen, Inc. and Amgen, Inc..
Which ETF is more diversified: FBT or PBE?
FBT holds 30 securities with 59.85% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 60.29%.
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Latest news about FBT & PBE
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