FBTvsPBEETF Comparison
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First Trust NYSE Arca Biotechnology Index Fund ETF (FBT) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. FBT is less expensive with a Total Expense Ratio (TER) of 0.54%, versus 0.58% for PBE. FBT is down -0.95% year-to-date (YTD) with +$1.07B in YTD flows. PBE performs worse with -3.02% YTD performance, and -$4M in YTD flows. Run a side-by-side ETF comparison of FBT and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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FBT vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | FBT PBE | +7.20%+3.54% | -7.12%-3.31% | -0.95%-3.02% | +26.96%+30.84% | +35.51%+28.68% | +23.43%+4.30% |
| Flows | FBT PBE | -+$18K | +$57M-$8M | +$1.07B-$4M | +$1.08B-$32M | +$617M-$60M | +$297M-$44M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | FBT PBE | +23.35%+19.47% | +21.73%+19.83% | +20.18%+20.12% | +21.87%+22.54% |
| Max drawdown | FBT PBE | -13.36%-9.36% | -14.27%-11.70% | -19.92%-22.21% | -29.98%-34.74% |
| Max drawdown duration | FBT PBE | 90d79d | 95d111d | 237d324d | 1243d1540d |
Trading data
FBT | PBE | |
Last sale 4/29/2026 at 1:30 PM | $200.65 | $78.51 |
| Previous close 04/28/2026 | $203.28 | $79.56 |
| Consolidated volume 04/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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FBT | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/29/2026 at 1:30 PM
Live
Closed
FBT | PBE | |
|---|---|---|
| Last price | $200.65 | $78.51 |
| 1D performance | -1.29% | -1.32% |
| AuM | $2.30 B | $247.37 M |
| E/R | 0.54% | 0.58% |
Characteristics
FBT | PBE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | First Trust | Invesco |
| Benchmark | NYSE Arca Biotechnology Index | Dynamic Biotech & Genome Intellidex Index |
| N° of holdings | 28 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | June 23, 2005 |
| ESG | No | No |
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Exposure
Countries
FBT
USA
95.76%
Other
4.24%
PBE
USA
92.18%
Other
7.82%
Sectors
FBT
Health Care
90.59%
Other
9.41%
PBE
Health Care
97.59%
Other
2.41%
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Diversification
FBT
Total weight of top 15 holdings out of 15
56.66%
PBE
Total weight of top 15 holdings out of 15
63.66%
Top 15 holdings
Data as of March 31, 2026
FBT
MODERNA INC
5.14%
ALKERMES
4.16%
UTD THERAPEUT
4.15%
GILEAD SCIENCES
4.08%
CORCEPT THERAPEUTICS
3.94%
AXSOME THERA CMN STK
3.91%
AMGEN-T
3.81%
EXELIXIS
3.52%
KRYSTAL BIOTECH INC
3.49%
BIOGEN INC
3.45%
NEUROCRINE BIOSCIENCES
3.44%
REGENERON PHARMACEUTICALS
3.44%
BIOMARIN PHARMACEUTICAL
3.42%
VERTEX PHARMACEUTICALS
3.39%
US04016X1019
3.32%
PBE
UTD THERAPEUT
6.05%
ILLUMINA
5.24%
REGENERON PHARMACEUTICALS
5.23%
ALNYLAM PHARMACEUTICALS
5.22%
BIOGEN INC
5.16%
AMGEN-T
4.99%
GILEAD SCIENCES
4.98%
INCYTE
4.89%
BIOCRYST PHARMACEUTICALS
3.66%
PROTAGONIST THERAPEUTICS INC
3.38%
TG THERAPEUTICS
3.11%
ROYALTY PHARMA
3.05%
NEUROCRINE BIOSCIENCES
2.93%
CATALYST PHARMACEUTICALS INC
2.89%
PTC THERAPEUTI/D
2.86%
Frequently asked questions about FBT and PBE
How have the FBT and PBE ETFs performed in 2026?
As of April 27, 2026, FBT is down -0.95% year-to-date (YTD), while PBE has lost -3.02%. That puts FBT better performer ahead so far this year.
Which ETF is attracting more investor money: FBT or PBE?
Year-to-date, the FBT ETF saw +$1.07B in flows, compared to -$4M for PBE.
Which ETF is more volatile: FBT or PBE?
Over the past year, FBT had a volatility of 21.73%, while PBE experienced 19.83%.
Which ETF is bigger: FBT or PBE?
As of April 27, 2026, FBT holds $2.30 B in assets under management (AUM), while PBE manages $247.37 M.
What sectors do the FBT and PBE ETFs invest in?
FBT leans toward sectors like Health Care. Meanwhile, PBE focuses on Health Care.
What are the top holdings of the FBT ETF and PBE ETF?
FBT top holdings include MODERNA INC, ALKERMES and UTD THERAPEUT. PBE holds in its top three: UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS.
Which ETF is more diversified: FBT or PBE?
FBT holds 30 securities with 56.66% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 63.66%.
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Latest news about FBT & PBE
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