FBTvsPBEETF Comparison
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First Trust NYSE Arca Biotechnology Index Fund ETF (FBT) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. Both ETFs have the same top 1 sector exposures: Healthcare. FBT is less expensive with a Total Expense Ratio (TER) of 0.54%, versus 0.59% for PBE. FBT is up 31.8% year-to-date (YTD) with +$1.00B in YTD flows. PBE performs worse with 22.24% YTD performance, and +$113M in YTD flows. Run a side-by-side ETF comparison of FBT and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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FBT vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/26/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | FBT PBE | -0.75%+2.00% | +9.93%+10.62% | +31.80%+22.24% | +42.46%+36.49% | +100.87%+87.45% | +65.30%+34.51% |
| Flows | FBT PBE | +$40M-$947K | -$22M+$111M | +$1.00B+$113M | +$1.09B+$115M | +$709M+$62M | +$348M+$65M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | FBT PBE | +22.81%+21.57% | +22.20%+20.01% | +21.23%+20.66% | +22.28%+22.69% |
| Max drawdown | FBT PBE | -5.30%-5.97% | -14.27%-11.70% | -19.92%-22.21% | -27.40%-32.63% |
| Max drawdown duration | FBT PBE | 60d46d | 126d166d | 237d324d | 1017d1468d |
Trading data
FBT | PBE | |
Last sale 10/27/2026 at 1:30 PM | $273.73 | $100.74 |
| Previous close 10/26/2026 | $271.47 | $99.21 |
| Consolidated volume 10/26/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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FBT | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
FBT | PBE | |
|---|---|---|
| Last price | $273.73 | $100.74 |
| 1D performance | +0.83% | +1.54% |
| AuM | $3.00 B | $431.86 M |
| E/R | 0.54% | 0.59% |
Characteristics
FBT | PBE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | First Trust | Invesco |
| Benchmark | NYSE Arca Biotechnology Index | Dynamic Biotech & Genome Intellidex Index |
| N° of holdings | 30 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | June 23, 2005 |
| ESG | No | No |
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Exposure
Countries
FBT
USA
82.68%
Other
17.32%
PBE
USA
97.22%
Other
2.78%
Sectors
FBT
Healthcare
99.86%
Other
0.14%
PBE
Healthcare
100%
Other
0%
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Diversification
FBT
Total weight of top 15 holdings out of 15
55.27%
PBE
Total weight of top 15 holdings out of 15
63.67%
Top 15 holdings
Data as of August 31, 2026
FBT
Halozyme Therapeutics, Inc.
4.38%
Regeneron Pharmaceuticals, Inc.
3.84%
NeoGenomics, Inc.
3.83%
Corcept Therapeutics, Inc.
3.82%
Amgen, Inc.
3.74%
BeOne Medicines Ltd.
3.72%
Natera, Inc.
3.68%
Repligen Corp.
3.65%
argenx SE
3.63%
Gilead Sciences, Inc.
3.58%
Genmab A/S
3.56%
Vertex Pharmaceuticals, Inc.
3.50%
Sarepta Therapeutics, Inc.
3.49%
BioNTech SE
3.45%
BioMarin Pharmaceutical, Inc.
3.40%
PBE
CareDx, Inc.
5.49%
Amgen, Inc.
5.38%
Regeneron Pharmaceuticals, Inc.
5.26%
Vertex Pharmaceuticals, Inc.
5.21%
Royalty Pharma Plc
4.76%
Biogen, Inc.
4.75%
Gilead Sciences, Inc.
4.61%
United Therapeutics Corp.
3.77%
Omeros Corp.
3.73%
Repligen Corp.
3.57%
Illumina, Inc.
3.54%
Halozyme Therapeutics, Inc.
3.51%
Bio-Techne Corp.
3.41%
Protagonist Therapeutics, Inc.
3.37%
Alnylam Pharmaceuticals, Inc.
3.31%
Frequently asked questions about FBT and PBE
How have the FBT and PBE ETFs performed in 2026?
As of October 26, 2026, FBT is up 31.8% year-to-date (YTD), while PBE has returned 22.24%. That puts FBT better performer ahead so far this year.
Which ETF is attracting more investor money: FBT or PBE?
Year-to-date, the FBT ETF saw +$1.00B in flows, compared to +$113M for PBE.
Which ETF is more volatile: FBT or PBE?
Over the past year, FBT had a volatility of 22.2%, while PBE experienced 20.01%.
Which ETF is bigger: FBT or PBE?
As of October 26, 2026, FBT holds $3.00 B in assets under management (AUM), while PBE manages $431.86 M.
What sectors do the FBT and PBE ETFs invest in?
FBT leans toward sectors like Healthcare. Meanwhile, PBE focuses on Healthcare.
What are the top holdings of the FBT ETF and PBE ETF?
FBT top holdings include Halozyme Therapeutics, Inc., Regeneron Pharmaceuticals, Inc. and NeoGenomics, Inc.. PBE holds in its top three: CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc..
Which ETF is more diversified: FBT or PBE?
FBT holds 30 securities with 55.27% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 63.67%.
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Latest news about FBT & PBE
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