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EKGvsPBEETF Comparison

ETF 1
EKG

First Trust Nasdaq Lux Digital Health Solutions ETF

This fund is part of
Healthcare Technology
-0.67%
VS
ETF 2
PBE

Invesco Dynamic Biotechnology & Genome ETF

This fund is part of
BioTech & Genomics
-5.05%

First Trust Nasdaq Lux Digital Health Solutions ETF (EKG) belongs to the Healthcare Technology segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. Both ETFs have the same top 1 sector exposures: Healthcare. EKG is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.59% for PBE. EKG is up 31.66% year-to-date (YTD) with +$6M in YTD flows. PBE performs worse with 26.2% YTD performance, and +$109M in YTD flows. Run a side-by-side ETF comparison of EKG and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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EKG vs PBE performance and flow charts

Performance

-4.0-2.00.02.04.06.0%Sep 29Oct 6Oct 13Oct 20Oct 27

Cumulative Flows

-6 M-4 M-2 M0 M2 M4 MSep 29Oct 6Oct 13Oct 20Oct 27

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Historic performance and flows
Data as of 10/29/2026
1M3MYTD1Y3Y5Y
Perf.
EKG
PBE
+5.76%+5.52%
+28.41%+12.47%
+31.66%+26.20%
+37.20%+42.26%
+107.33%+97.72%
n/a+36.83%
Flows
EKG
PBE
+$5M-$5M
+$5M+$106M
+$6M+$109M
+$6M+$111M
+$7M+$58M
-+$61M
Volatility and drawdown
3M1Y3Y5Y
Volatility
EKG
PBE
+25.55%+21.50%
+24.43%+20.03%
+23.86%+20.60%
n/a+22.66%
Max drawdown
EKG
PBE
-5.73%-5.97%
-22.11%-11.70%
-24.32%-22.21%
n/a-32.63%
Max drawdown duration
EKG
PBE
21d46d
208d166d
264d324d
n/a1468d
Trading data

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EKG
PBE
Last sale
10/30/2026 at 1:30 PM
$23.93
$102.50
Previous close
10/29/2026
$25.00
$103.46
Consolidated volume
10/29/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of October 30, 2026
1-year trailing difference

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EKG
PBE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 10/30/2026 at 1:30 PM
Live
Closed
EKG
PBE
Last price
$23.93
$102.50
1D performance
-4.30%
-0.93%
AuM$10.01 M$441.78 M
E/R0.65%0.59%
Characteristics
EKG
PBE
Management strategyPassivePassive
ProviderFirst TrustInvesco
BenchmarkNasdaq Lux Health Tech IndexDynamic Biotech & Genome Intellidex Index
N° of holdings5130
Asset classEquitiesEquities
Trailing 12m distribution yield
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Inception dateMarch 22, 2022June 23, 2005
ESGNoNo
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Exposure

Countries

EKG
USA
96.91%
Other
3.09%
PBE
USA
97.15%
Other
2.85%

Sectors

EKG
Healthcare
99.9%
Other
0.1%
PBE
Healthcare
100%
Other
0%
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Diversification

EKG

Total weight of top 15 holdings out of 15

72.5%
PBE

Total weight of top 15 holdings out of 15

62.68%

Top 15 holdings

Data as of September 30, 2026
EKG
Natera, Inc.
9.62%
Intuitive Surgical, Inc.
8.07%
IQVIA Holdings, Inc.
7.56%
Veeva Systems, Inc.
7.47%
DexCom, Inc.
7.18%
Illumina, Inc.
4.71%
Guardant Health, Inc.
4.16%
ResMed, Inc.
3.48%
Globus Medical, Inc.
3.21%
Tempus AI, Inc.
3.06%
QIAGEN NV
2.99%
Twist Bioscience Corp.
2.85%
Align Technology, Inc.
2.75%
Insulet Corp.
2.73%
Oscar Health, Inc.
2.66%
PBE
Natera, Inc.
6.20%
Illumina, Inc.
6.13%
Biogen, Inc.
5.25%
Gilead Sciences, Inc.
5.19%
Vertex Pharmaceuticals, Inc.
4.84%
Amgen, Inc.
4.79%
Royalty Pharma Plc
4.77%
Regeneron Pharmaceuticals, Inc.
4.57%
Moderna, Inc.
3.43%
Novavax, Inc.
3.16%
Repligen Corp.
2.95%
Halozyme Therapeutics, Inc.
2.86%
QIAGEN NV
2.85%
Exelixis, Inc.
2.85%
Veracyte, Inc.
2.84%
Frequently asked questions about EKG and PBE

How have the EKG and PBE ETFs performed in 2026?

As of October 29, 2026, EKG is up 31.66% year-to-date (YTD), while PBE has returned 26.2%. That puts EKG better performer ahead so far this year.

Which ETF is attracting more investor money: EKG or PBE?

Year-to-date, the EKG ETF saw +$6M in flows, compared to +$109M for PBE.

Which ETF is more volatile: EKG or PBE?

Over the past year, EKG had a volatility of 24.43%, while PBE experienced 20.03%.

Which ETF is bigger: EKG or PBE?

As of October 29, 2026, EKG holds $10.01 M in assets under management (AUM), while PBE manages $441.78 M.

What sectors do the EKG and PBE ETFs invest in?

EKG leans toward sectors like Healthcare. Meanwhile, PBE focuses on Healthcare.

What are the top holdings of the EKG ETF and PBE ETF?

EKG top holdings include Natera, Inc., Intuitive Surgical, Inc. and IQVIA Holdings, Inc.. PBE holds in its top three: Natera, Inc., Illumina, Inc. and Biogen, Inc..

Which ETF is more diversified: EKG or PBE?

EKG holds 51 securities with 72.5% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 62.68%.

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