CANCvsWDNAETF Comparison
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Tema Oncology ETF (CANC) belongs to the Tomorrow's Treatments segment. WisdomTree BioRevolution Fund (WDNA) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Healthcare. CANC is more expensive with a Total Expense Ratio (TER) of 0.99%, versus 0.45% for WDNA. CANC is up 18.39% year-to-date (YTD) with +$52M in YTD flows. WDNA performs worse with 16.03% YTD performance, and -$357K in YTD flows. Run a side-by-side ETF comparison of CANC and WDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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CANC vs WDNA performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | CANC WDNA | +4.80%+0.63% | +7.02%+10.94% | +18.39%+16.03% | +52.92%+37.68% | n/a+14.16% | n/a-18.31% |
| Flows | CANC WDNA | -$2M- | +$3M- | +$52M-$357K | +$76M-$357K | --$524K | -+$1M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | CANC WDNA | +23.23%+23.94% | +22.67%+25.34% | n/a+25.05% | n/a+24.98% |
| Max drawdown | CANC WDNA | -5.93%-8.58% | -9.20%-11.90% | n/a-37.36% | n/a-58.58% |
| Max drawdown duration | CANC WDNA | 47d17d | 67d147d | n/a876d | n/a1786d |
Trading data
CANC | WDNA | |
Last sale 7/27/2026 at 1:30 PM | $41.10 | $19.69 |
| Previous close 07/24/2026 | $41.07 | $19.66 |
| Consolidated volume 07/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of July 28, 2026
1-year trailing difference
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CANC
is actively managed and doesn’t replicate an indexCANC | WDNA | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/27/2026 at 1:30 PM
Live
Closed
CANC | WDNA | |
|---|---|---|
| Last price | $41.10 | $19.69 |
| 1D performance | +0.09% | +0.14% |
| AuM | $195.60 M | $2.55 M |
| E/R | 0.99% | 0.45% |
Characteristics
CANC | WDNA | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | Tema | WisdomTree |
| Benchmark | - | WisdomTree BioRevolution Index |
| N° of holdings | 56 | 80 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | August 15, 2023 | June 3, 2021 |
| ESG | No | No |
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Exposure
Countries
CANC
USA
80.59%
Switzerland
9.85%
Other
9.56%
WDNA
USA
83.72%
Other
16.28%
Sectors
CANC
Healthcare
99.28%
Other
0.72%
WDNA
Healthcare
89.22%
Other
10.78%
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Diversification
CANC
Total weight of top 15 holdings out of 15
55.76%
WDNA
Total weight of top 15 holdings out of 15
39.68%
Top 15 holdings
Data as of June 30, 2026
CANC
Revolution Medicines, Inc.
6.32%
Eli Lilly & Co.
5.24%
Cogent Biosciences, Inc.
4.94%
Novartis AG
4.19%
Roche Holding AG
3.93%
Legend Biotech Corp.
3.70%
Merck & Co., Inc.
3.66%
Bristol Myers Squibb Co.
3.33%
AstraZeneca PLC
3.15%
Johnson & Johnson
3.09%
AbbVie, Inc.
3.08%
Immunome, Inc.
2.87%
Exelixis, Inc.
2.85%
Nuvalent, Inc.
2.73%
IDEAYA Biosciences, Inc.
2.68%
WDNA
Twist Bioscience Corp.
5.81%
Eli Lilly & Co.
3.98%
Moderna, Inc.
3.67%
Johnson & Johnson
2.98%
United Therapeutics Corp.
2.55%
Natera, Inc.
2.32%
Tempus AI, Inc.
2.25%
Immunome, Inc.
2.15%
Beam Therapeutics, Inc.
2.14%
Stoke Therapeutics, Inc.
2.02%
Corteva, Inc.
1.99%
Structure Therapeutics, Inc.
1.98%
Krystal Biotech, Inc.
1.97%
Darling Ingredients, Inc.
1.96%
Ionis Pharmaceuticals, Inc.
1.91%
Frequently asked questions about CANC and WDNA
How have the CANC and WDNA ETFs performed in 2026?
As of July 24, 2026, CANC is up 18.39% year-to-date (YTD), while WDNA has returned 16.03%. That puts CANC better performer ahead so far this year.
Which ETF is attracting more investor money: CANC or WDNA?
Year-to-date, the CANC ETF saw +$52M in flows, compared to -$357K for WDNA.
Which ETF is more volatile: CANC or WDNA?
Over the past year, CANC had a volatility of 22.67%, while WDNA experienced 25.34%.
Which ETF is bigger: CANC or WDNA?
As of July 24, 2026, CANC holds $195.60 M in assets under management (AUM), while WDNA manages $2.55 M.
What sectors do the CANC and WDNA ETFs invest in?
CANC leans toward sectors like Healthcare. Meanwhile, WDNA focuses on Healthcare.
What are the top holdings of the CANC ETF and WDNA ETF?
CANC top holdings include Revolution Medicines, Inc., Eli Lilly & Co. and Cogent Biosciences, Inc.. WDNA holds in its top three: Twist Bioscience Corp., Eli Lilly & Co. and Moderna, Inc..
Which ETF is more diversified: CANC or WDNA?
CANC holds 56 securities with 55.76% of its assets in the top 15. WDNA has 80 securities and a top 15 weight of 39.68%.
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