CANCvsIBBQETF Comparison
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Tema Oncology ETF (CANC) belongs to the Tomorrow's Treatments segment. Invesco Nasdaq Biotechnology ETF (IBBQ) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Healthcare. CANC is more expensive with a Total Expense Ratio (TER) of 0.99%, versus 0.19% for IBBQ. CANC is up 18.41% year-to-date (YTD) with +$52M in YTD flows. IBBQ performs worse with 14.36% YTD performance, and +$3M in YTD flows. Run a side-by-side ETF comparison of CANC and IBBQ below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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CANC vs IBBQ performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | CANC IBBQ | -0.28%-0.78% | +8.61%+11.01% | +18.41%+14.36% | +53.77%+45.69% | n/a+63.55% | n/a+33.80% |
| Flows | CANC IBBQ | -$2M+$4M | +$3M+$3M | +$52M+$3M | +$76M+$23M | -+$39M | -+$3M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | CANC IBBQ | +23.01%+22.64% | +22.71%+20.27% | n/a+20.27% | n/a+21.99% |
| Max drawdown | CANC IBBQ | -5.93%-5.97% | -9.20%-8.38% | n/a-23.78% | n/a-38.09% |
| Max drawdown duration | CANC IBBQ | 47d20d | 67d48d | n/a375d | n/a1543d |
Trading data
CANC | IBBQ | |
Last sale 7/28/2026 at 1:30 PM | $41.18 | $32.76 |
| Previous close 07/27/2026 | $41.10 | $32.42 |
| Consolidated volume 07/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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CANC
is actively managed and doesn’t replicate an indexCANC | IBBQ | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 7/28/2026 at 1:30 PM
Live
Closed
CANC | IBBQ | |
|---|---|---|
| Last price | $41.18 | $32.76 |
| 1D performance | +0.20% | +1.04% |
| AuM | $195.62 M | $75.76 M |
| E/R | 0.99% | 0.19% |
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Exposure
Countries
CANC
USA
80.59%
Switzerland
9.85%
Other
9.56%
IBBQ
USA
88.1%
Other
11.9%
Sectors
CANC
Healthcare
99.28%
Other
0.72%
IBBQ
Healthcare
99.98%
Other
0.02%
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Diversification
CANC
Total weight of top 15 holdings out of 15
55.76%
IBBQ
Total weight of top 15 holdings out of 15
49.38%
Top 15 holdings
Data as of June 30, 2026
CANC
Revolution Medicines, Inc.
6.32%
Eli Lilly & Co.
5.24%
Cogent Biosciences, Inc.
4.94%
Novartis AG
4.19%
Roche Holding AG
3.93%
Legend Biotech Corp.
3.70%
Merck & Co., Inc.
3.66%
Bristol Myers Squibb Co.
3.33%
AstraZeneca PLC
3.15%
Johnson & Johnson
3.09%
AbbVie, Inc.
3.08%
Immunome, Inc.
2.87%
Exelixis, Inc.
2.85%
Nuvalent, Inc.
2.73%
IDEAYA Biosciences, Inc.
2.68%
IBBQ
Vertex Pharmaceuticals, Inc.
8.16%
Amgen, Inc.
7.91%
Gilead Sciences, Inc.
7.07%
Regeneron Pharmaceuticals, Inc.
4.62%
Alnylam Pharmaceuticals, Inc.
2.76%
Revolution Medicines, Inc.
2.74%
Biogen, Inc.
2.26%
Illumina, Inc.
1.89%
Moderna, Inc.
1.89%
Royalty Pharma Plc
1.77%
Roivant Sciences Ltd.
1.74%
argenx SE
1.73%
United Therapeutics Corp.
1.63%
Incyte Corp.
1.61%
Insmed, Inc.
1.59%
Frequently asked questions about CANC and IBBQ
How have the CANC and IBBQ ETFs performed in 2026?
As of July 27, 2026, CANC is up 18.41% year-to-date (YTD), while IBBQ has returned 14.36%. That puts CANC better performer ahead so far this year.
Which ETF is attracting more investor money: CANC or IBBQ?
Year-to-date, the CANC ETF saw +$52M in flows, compared to +$3M for IBBQ.
Which ETF is more volatile: CANC or IBBQ?
Over the past year, CANC had a volatility of 22.71%, while IBBQ experienced 20.27%.
Which ETF is bigger: CANC or IBBQ?
As of July 27, 2026, CANC holds $195.62 M in assets under management (AUM), while IBBQ manages $75.76 M.
What sectors do the CANC and IBBQ ETFs invest in?
CANC leans toward sectors like Healthcare. Meanwhile, IBBQ focuses on Healthcare.
What are the top holdings of the CANC ETF and IBBQ ETF?
CANC top holdings include Revolution Medicines, Inc., Eli Lilly & Co. and Cogent Biosciences, Inc.. IBBQ holds in its top three: Vertex Pharmaceuticals, Inc., Amgen, Inc. and Gilead Sciences, Inc..
Which ETF is more diversified: CANC or IBBQ?
CANC holds 56 securities with 55.76% of its assets in the top 15. IBBQ has 251 securities and a top 15 weight of 49.38%.
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