CANCvsHELXETF Comparison
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Tema Oncology ETF (CANC) belongs to the Tomorrow's Treatments segment. Franklin Genomic Advancements ETF (HELX) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Healthcare. CANC is more expensive with a Total Expense Ratio (TER) of 0.99%, versus 0.5% for HELX. CANC is up 18.41% year-to-date (YTD) with +$52M in YTD flows. HELX performs worse with 7.06% YTD performance, and +$6M in YTD flows. Run a side-by-side ETF comparison of CANC and HELX below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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CANC vs HELX performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | CANC HELX | -0.28%-2.99% | +8.61%+15.45% | +18.41%+7.06% | +53.77%+38.11% | n/a+25.32% | n/a-23.15% |
| Flows | CANC HELX | -$2M+$4M | +$3M+$4M | +$52M+$6M | +$76M+$10M | -+$13M | -+$18M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | CANC HELX | +23.01%+24.88% | +22.71%+21.77% | n/a+20.98% | n/a+23.61% |
| Max drawdown | CANC HELX | -5.93%-6.59% | -9.20%-17.89% | n/a-29.16% | n/a-58.50% |
| Max drawdown duration | CANC HELX | 47d18d | 67d206d | n/a458d | n/a1784d |
Trading data
CANC | HELX | |
Last sale 7/28/2026 at 1:30 PM | $41.18 | $39.13 |
| Previous close 07/27/2026 | $41.10 | $38.86 |
| Consolidated volume 07/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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Main metrics
Last update 7/28/2026 at 1:30 PM
Live
Closed
CANC | HELX | |
|---|---|---|
| Last price | $41.18 | $39.13 |
| 1D performance | +0.20% | +0.70% |
| AuM | $195.62 M | $29.14 M |
| E/R | 0.99% | 0.5% |
Characteristics
CANC | HELX | |
|---|---|---|
| Management strategy | Active | Active |
| Provider | Tema | Franklin Templeton |
| Benchmark | - | - |
| N° of holdings | 56 | 61 |
| Asset class | - | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | August 15, 2023 | February 25, 2020 |
| ESG | No | No |
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Exposure
Countries
CANC
USA
80.59%
Switzerland
9.85%
Other
9.56%
HELX
USA
87.84%
Other
12.16%
Sectors
CANC
Healthcare
99.28%
Other
0.72%
HELX
Healthcare
96.75%
Other
3.25%
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Diversification
CANC
Total weight of top 15 holdings out of 15
55.76%
HELX
Total weight of top 15 holdings out of 15
59.93%
Top 15 holdings
Data as of June 30, 2026
CANC
Revolution Medicines, Inc.
6.32%
Eli Lilly & Co.
5.24%
Cogent Biosciences, Inc.
4.94%
Novartis AG
4.19%
Roche Holding AG
3.93%
Legend Biotech Corp.
3.70%
Merck & Co., Inc.
3.66%
Bristol Myers Squibb Co.
3.33%
AstraZeneca PLC
3.15%
Johnson & Johnson
3.09%
AbbVie, Inc.
3.08%
Immunome, Inc.
2.87%
Exelixis, Inc.
2.85%
Nuvalent, Inc.
2.73%
IDEAYA Biosciences, Inc.
2.68%
HELX
Guardant Health, Inc.
9.30%
Natera, Inc.
7.40%
Krystal Biotech, Inc.
6.51%
Ligand Pharmaceuticals, Inc.
4.56%
Adaptive Biotechnologies Corp.
4.01%
United Therapeutics Corp.
3.61%
BridgeBio Pharma, Inc.
3.39%
Eli Lilly & Co.
3.05%
Twist Bioscience Corp.
2.84%
Vertex Pharmaceuticals, Inc.
2.79%
Travere Therapeutics, Inc.
2.76%
AstraZeneca PLC
2.76%
Insmed, Inc.
2.43%
Corteva, Inc.
2.26%
SAMSUNG BIOLOGICS Co., Ltd.
2.26%
Frequently asked questions about CANC and HELX
How have the CANC and HELX ETFs performed in 2026?
As of July 27, 2026, CANC is up 18.41% year-to-date (YTD), while HELX has returned 7.06%. That puts CANC better performer ahead so far this year.
Which ETF is attracting more investor money: CANC or HELX?
Year-to-date, the CANC ETF saw +$52M in flows, compared to +$6M for HELX.
Which ETF is more volatile: CANC or HELX?
Over the past year, CANC had a volatility of 22.71%, while HELX experienced 21.77%.
Which ETF is bigger: CANC or HELX?
As of July 27, 2026, CANC holds $195.62 M in assets under management (AUM), while HELX manages $29.14 M.
What sectors do the CANC and HELX ETFs invest in?
CANC leans toward sectors like Healthcare. Meanwhile, HELX focuses on Healthcare.
What are the top holdings of the CANC ETF and HELX ETF?
CANC top holdings include Revolution Medicines, Inc., Eli Lilly & Co. and Cogent Biosciences, Inc.. HELX holds in its top three: Guardant Health, Inc., Natera, Inc. and Krystal Biotech, Inc..
Which ETF is more diversified: CANC or HELX?
CANC holds 56 securities with 55.76% of its assets in the top 15. HELX has 61 securities and a top 15 weight of 59.93%.
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