BBPvsXHEETF Comparison
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Virtus LifeSci Biotech Products ETF (BBP) belongs to the Tomorrow's Treatments segment. State Street SPDR S&P Health Care Equipment ETF (XHE) is part of the US Health Care segment. BBP's top 1 sector exposures are Healthcare. In contrast, XHE's top sector exposures are Healthcare and Finance. BBP is less expensive with a Total Expense Ratio (TER) of 0.34%, versus 0.35% for XHE. BBP is up 29.59% year-to-date (YTD) with +$61M in YTD flows. XHE performs worse with 2.14% YTD performance, and +$11M in YTD flows. Run a side-by-side ETF comparison of BBP and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBP vs XHE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBP XHE | +1.58%-5.10% | +19.06%+9.79% | +29.59%+2.14% | +46.60%+9.32% | +94.97%+7.53% | +99.54%-30.21% |
| Flows | BBP XHE | +$16M+$3M | +$31M+$12M | +$61M+$11M | +$72M-$245K | +$78M-$266M | +$71M-$382M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBP XHE | +25.64%+24.14% | +25.15%+22.69% | +24.71%+22.22% | +26.61%+24.84% |
| Max drawdown | BBP XHE | -9.34%-7.53% | -9.59%-18.20% | -25.54%-24.35% | -37.61%-49.37% |
| Max drawdown duration | BBP XHE | 39d23d | 48d207d | 292d565d | 586d1773d |
Trading data
BBP | XHE | |
Last sale 9/11/2026 at 1:30 PM | $103.46 | $90.01 |
| Previous close 09/10/2026 | $103.47 | $89.53 |
| Consolidated volume 09/10/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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BBP | XHE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/11/2026 at 1:30 PM
Live
Closed
BBP | XHE | |
|---|---|---|
| Last price | $103.46 | $90.01 |
| 1D performance | -0.01% | +0.54% |
| AuM | $124.03 M | $168.78 M |
| E/R | 0.34% | 0.35% |
Characteristics
BBP | XHE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | State Street Investment Management |
| Benchmark | LifeSci Biotechnology Products Index | S&P Health Care Equipment Select Industry Index |
| N° of holdings | 66 | 66 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | January 26, 2011 |
| ESG | No | No |
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Exposure
Countries
BBP
USA
86.5%
Other
13.5%
XHE
USA
93.56%
Other
6.44%
Sectors
BBP
Healthcare
98.2%
Other
1.8%
XHE
Healthcare
98.72%
Other
1.28%
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Diversification
BBP
Total weight of top 15 holdings out of 15
26.78%
XHE
Total weight of top 15 holdings out of 15
30.19%
Top 15 holdings
Data as of July 31, 2026
BBP
Crinetics Pharmaceuticals, Inc.
3.24%
Verastem, Inc.
1.98%
Nuvation Bio, Inc.
1.80%
Omeros Corp.
1.73%
Geron Corp.
1.72%
BridgeBio Pharma, Inc.
1.68%
Agios Pharmaceuticals, Inc.
1.67%
Protagonist Therapeutics, Inc.
1.65%
BeOne Medicines Ltd.
1.64%
Kiniksa Pharmaceuticals International Plc
1.63%
Precigen, Inc.
1.62%
Xeris Biopharma Holdings, Inc.
1.61%
ACADIA Pharmaceuticals, Inc.
1.60%
Iovance Biotherapeutics, Inc.
1.60%
Rhythm Pharmaceuticals, Inc.
1.60%
XHE
AtriCure, Inc.
2.14%
Glaukos Corp.
2.13%
Dentsply Sirona, Inc.
2.08%
Enovis Corp.
2.07%
Integer Holdings Corp.
2.07%
Butterfly Network, Inc.
2.06%
Neogen Corp.
2.05%
Artivion, Inc.
2.05%
Baxter International, Inc.
2.01%
CONMED Corp.
1.99%
Merit Medical Systems, Inc.
1.98%
QuidelOrtho Corp.
1.94%
ICU Medical, Inc.
1.88%
Tandem Diabetes Care, Inc.
1.88%
Inspire Medical Systems, Inc.
1.85%
Frequently asked questions about BBP and XHE
How have the BBP and XHE ETFs performed in 2026?
As of September 11, 2026, BBP is up 29.59% year-to-date (YTD), while XHE has returned 2.14%. That puts BBP better performer ahead so far this year.
Which ETF is attracting more investor money: BBP or XHE?
Year-to-date, the BBP ETF saw +$61M in flows, compared to +$11M for XHE.
Which ETF is more volatile: BBP or XHE?
Over the past year, BBP had a volatility of 25.15%, while XHE experienced 22.69%.
Which ETF is bigger: BBP or XHE?
As of September 11, 2026, BBP holds $124.03 M in assets under management (AUM), while XHE manages $168.78 M.
What sectors do the BBP and XHE ETFs invest in?
BBP leans toward sectors like Healthcare. Meanwhile, XHE focuses on Healthcare.
What are the top holdings of the BBP ETF and XHE ETF?
BBP top holdings include Crinetics Pharmaceuticals, Inc., Verastem, Inc. and Nuvation Bio, Inc.. XHE holds in its top three: AtriCure, Inc., Glaukos Corp. and Dentsply Sirona, Inc..
Which ETF is more diversified: BBP or XHE?
BBP holds 66 securities with 26.78% of its assets in the top 15. XHE has 66 securities and a top 15 weight of 30.19%.
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