BBPvsIBRNETF Comparison
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Virtus LifeSci Biotech Products ETF (BBP) belongs to the Tomorrow's Treatments segment. iShares Neuroscience and Healthcare ETF (IBRN) is part of the Healthcare Technology segment. BBP's top 1 sector exposures are Healthcare. In contrast, IBRN's top sector exposures are Healthcare and Non-Corporate. BBP is less expensive with a Total Expense Ratio (TER) of 0.34%, versus 0.47% for IBRN. BBP is up 28.37% year-to-date (YTD) with +$66M in YTD flows. IBRN performs worse with -2.14% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of BBP and IBRN below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBP vs IBRN performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/26/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBP IBRN | -2.65%-5.40% | +5.62%-15.92% | +28.37%-2.14% | +38.01%+5.97% | +119.28%+62.93% | +100.33%n/a |
| Flows | BBP IBRN | -- | +$26M+$2M | +$66M+$2M | +$78M+$2M | +$83M+$759K | +$76M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBP IBRN | +28.32%+26.25% | +26.44%+26.63% | +24.98%+25.50% | +26.86%n/a |
| Max drawdown | BBP IBRN | -8.70%-26.38% | -9.59%-26.38% | -25.54%-34.98% | -37.61%n/a |
| Max drawdown duration | BBP IBRN | 68d68d | 48d68d | 292d338d | 586dn/a |
Trading data
BBP | IBRN | |
Last sale 10/27/2026 at 1:30 PM | $104.89 | $32.24 |
| Previous close 10/26/2026 | $102.33 | $31.60 |
| Consolidated volume 10/26/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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BBP | IBRN | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
BBP | IBRN | |
|---|---|---|
| Last price | $104.89 | $32.24 |
| 1D performance | +2.50% | +2.03% |
| AuM | $127.99 M | $6.32 M |
| E/R | 0.34% | 0.47% |
Characteristics
BBP | IBRN | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | iShares |
| Benchmark | LifeSci Biotechnology Products Index | NYSE FactSet Global Neuro Biopharma and MedTech Index |
| N° of holdings | 66 | 69 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | August 24, 2022 |
| ESG | No | No |
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Exposure
Countries
BBP
USA
85.98%
Other
14.02%
IBRN
USA
73.41%
Other
26.59%
Sectors
BBP
Healthcare
98.44%
Other
1.56%
IBRN
Healthcare
99.86%
Other
0.14%
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Diversification
BBP
Total weight of top 15 holdings out of 15
31.08%
IBRN
Total weight of top 15 holdings out of 15
62.03%
Top 15 holdings
Data as of August 31, 2026
BBP
Moderna, Inc.
3.58%
Crinetics Pharmaceuticals, Inc.
2.94%
Omeros Corp.
2.49%
Iovance Biotherapeutics, Inc.
2.36%
Verastem, Inc.
2.15%
Precigen, Inc.
1.99%
Halozyme Therapeutics, Inc.
1.84%
Zai Lab Ltd.
1.82%
Kiniksa Pharmaceuticals International Plc
1.81%
Kura Oncology, Inc.
1.72%
BeOne Medicines Ltd.
1.70%
Rigel Pharmaceuticals, Inc.
1.69%
Nuvation Bio, Inc.
1.69%
ACADIA Pharmaceuticals, Inc.
1.67%
Protagonist Therapeutics, Inc.
1.65%
IBRN
Praxis Precision Medicines, Inc.
5.21%
Dianthus Therapeutics, Inc.
4.96%
ACADIA Pharmaceuticals, Inc.
4.93%
Scholar Rock Holding Corp.
4.85%
Xenon Pharmaceuticals, Inc.
4.40%
argenx SE
4.37%
Arrowhead Pharmaceuticals, Inc.
4.26%
Biogen, Inc.
4.19%
Alkermes Plc
4.15%
PTC Therapeutics, Inc.
3.70%
Denali Therapeutics, Inc.
3.56%
Neurocrine Biosciences, Inc.
3.55%
Dyne Therapeutics, Inc.
3.38%
Edgewise Therapeutics, Inc.
3.30%
Axsome Therapeutics, Inc.
3.23%
Frequently asked questions about BBP and IBRN
How have the BBP and IBRN ETFs performed in 2026?
As of October 26, 2026, BBP is up 28.37% year-to-date (YTD), while IBRN has lost -2.14%. That puts BBP better performer ahead so far this year.
Which ETF is attracting more investor money: BBP or IBRN?
Year-to-date, the BBP ETF saw +$66M in flows, compared to +$2M for IBRN.
Which ETF is more volatile: BBP or IBRN?
Over the past year, BBP had a volatility of 26.44%, while IBRN experienced 26.63%.
Which ETF is bigger: BBP or IBRN?
As of October 26, 2026, BBP holds $127.99 M in assets under management (AUM), while IBRN manages $6.32 M.
What sectors do the BBP and IBRN ETFs invest in?
BBP leans toward sectors like Healthcare. Meanwhile, IBRN focuses on Healthcare.
What are the top holdings of the BBP ETF and IBRN ETF?
BBP top holdings include Moderna, Inc., Crinetics Pharmaceuticals, Inc. and Omeros Corp.. IBRN holds in its top three: Praxis Precision Medicines, Inc., Dianthus Therapeutics, Inc. and ACADIA Pharmaceuticals, Inc..
Which ETF is more diversified: BBP or IBRN?
BBP holds 66 securities with 31.08% of its assets in the top 15. IBRN has 69 securities and a top 15 weight of 62.03%.
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