ARKGvsIBRNETF Comparison
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ARK Genomic Revolution ETF (ARKG) belongs to the BioTech & Genomics segment. iShares Neuroscience and Healthcare ETF (IBRN) is part of the Healthcare Technology segment. ARKG's top 1 sector exposures are Healthcare. In contrast, IBRN's top sector exposures are Healthcare and Non-Corporate. ARKG is more expensive with a Total Expense Ratio (TER) of 0.75%, versus 0.47% for IBRN. ARKG is up 55.92% year-to-date (YTD) with +$33M in YTD flows. IBRN performs worse with 15.7% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of ARKG and IBRN below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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ARKG vs IBRN performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | ARKG IBRN | +2.07%-4.78% | +35.35%+7.91% | +55.92%+15.70% | +73.72%+45.60% | +44.39%+66.79% | -43.98%n/a |
| Flows | ARKG IBRN | +$57M- | +$127M+$2M | +$33M+$2M | +$51M+$2M | -$523M+$759K | -$2.24B- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | ARKG IBRN | +42.98%+23.60% | +43.87%+25.91% | +43.91%+25.19% | +46.35%n/a |
| Max drawdown | ARKG IBRN | -13.89%-9.28% | -27.52%-9.28% | -46.41%-34.98% | -78.04%n/a |
| Max drawdown duration | ARKG IBRN | 32d40d | 126d40d | 882d338d | 1818dn/a |
Trading data
ARKG | IBRN | |
Last sale 9/11/2026 at 1:30 PM | $45.56 | $37.43 |
| Previous close 09/10/2026 | $45.38 | $37.33 |
| Consolidated volume 09/10/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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ARKG
is actively managed and doesn’t replicate an indexARKG | IBRN | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/11/2026 at 1:30 PM
Live
Closed
ARKG | IBRN | |
|---|---|---|
| Last price | $45.56 | $37.43 |
| 1D performance | +0.40% | +0.26% |
| AuM | $1.83 B | $7.48 M |
| E/R | 0.75% | 0.47% |
Characteristics
ARKG | IBRN | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | Ark Investment | iShares |
| Benchmark | - | NYSE FactSet Global Neuro Biopharma and MedTech Index |
| N° of holdings | 31 | 69 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | April 2, 2019 | August 24, 2022 |
| ESG | No | No |
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Exposure
Countries
ARKG
USA
88.43%
Other
11.57%
IBRN
USA
73.57%
Other
26.43%
Sectors
ARKG
Healthcare
97.99%
Other
2.01%
IBRN
Healthcare
99.87%
Other
0.13%
Diversification
ARKG
Total weight of top 15 holdings out of 15
75.55%
IBRN
Total weight of top 15 holdings out of 15
64.26%
Top 15 holdings
Data as of July 31, 2026
ARKG
10X Genomics, Inc.
9.41%
Twist Bioscience Corp.
7.74%
Tempus AI, Inc.
6.57%
CRISPR Therapeutics AG
6.30%
Personalis, Inc.
5.48%
Absci Corp.
5.15%
Guardant Health, Inc.
4.75%
Illumina, Inc.
4.75%
Eli Lilly & Co.
4.69%
CareDx, Inc.
4.31%
Natera, Inc.
4.14%
Beam Therapeutics, Inc.
3.78%
Compass Pathways Plc
3.26%
Recursion Pharmaceuticals, Inc.
2.63%
Adaptive Biotechnologies Corp.
2.58%
IBRN
Dianthus Therapeutics, Inc.
5.45%
Xenon Pharmaceuticals, Inc.
4.83%
Praxis Precision Medicines, Inc.
4.72%
ACADIA Pharmaceuticals, Inc.
4.66%
Arrowhead Pharmaceuticals, Inc.
4.65%
Alkermes Plc
4.55%
Neurocrine Biosciences, Inc.
4.41%
Scholar Rock Holding Corp.
4.31%
PTC Therapeutics, Inc.
4.15%
Biogen, Inc.
4.15%
Axsome Therapeutics, Inc.
3.93%
argenx SE
3.82%
Denali Therapeutics, Inc.
3.76%
Dyne Therapeutics, Inc.
3.53%
Edgewise Therapeutics, Inc.
3.35%
Frequently asked questions about ARKG and IBRN
How have the ARKG and IBRN ETFs performed in 2026?
As of September 11, 2026, ARKG is up 55.92% year-to-date (YTD), while IBRN has returned 15.7%. That puts ARKG better performer ahead so far this year.
Which ETF is attracting more investor money: ARKG or IBRN?
Year-to-date, the ARKG ETF saw +$33M in flows, compared to +$2M for IBRN.
Which ETF is more volatile: ARKG or IBRN?
Over the past year, ARKG had a volatility of 43.87%, while IBRN experienced 25.91%.
Which ETF is bigger: ARKG or IBRN?
As of September 11, 2026, ARKG holds $1.83 B in assets under management (AUM), while IBRN manages $7.48 M.
What sectors do the ARKG and IBRN ETFs invest in?
ARKG leans toward sectors like Healthcare. Meanwhile, IBRN focuses on Healthcare.
What are the top holdings of the ARKG ETF and IBRN ETF?
ARKG top holdings include 10X Genomics, Inc., Twist Bioscience Corp. and Tempus AI, Inc.. IBRN holds in its top three: Dianthus Therapeutics, Inc., Xenon Pharmaceuticals, Inc. and Praxis Precision Medicines, Inc..
Which ETF is more diversified: ARKG or IBRN?
ARKG holds 31 securities with 75.55% of its assets in the top 15. IBRN has 69 securities and a top 15 weight of 64.26%.
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